Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

doi:10.1186/s13046-021-02001-w

	Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation
	Dou,Zhihui 1,2,3,7; Zhao,Dapeng 1,2,3,7; Chen,Xiaohua 1,2,3,7; Xu,Caipeng 1,2,3,7; Jin,Xiaodong 1,7; Zhang,Xuetian 1,2,3,7; Wang,Yupei 4; Xie,Xiaodong 5; Li,Qiang 1,2,3,6,7; Di,Cuixia 1,2,3,6,7
刊名	Journal of Experimental & Clinical Cancer Research
	2021-06-12
卷号	40 期号:1
关键词	Bcl-x Alternative splicing Cell apoptosis Splicing correction Splice-switching oligonucleotides Small molecular modulators
DOI	10.1186/s13046-021-02001-w
通讯作者	Di,Cuixia(dicx@impcas.ac.cn) ; Zhang,Hong(zhang.h@impcas.ac.cn)
英文摘要	AbstractBcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development of multiple human diseases, especially cancers. Exploring the mechanism of Bcl-x splicing and regulation has provided insight into the development of drugs that could contribute to sensitivity of cancer cells to death. On this basis, we review the multiple splicing patterns and structural characteristics of Bcl-x. Additionally, we outline the cis-regulatory elements, trans-acting factors as well as epigenetic modifications involved in the splicing regulation of Bcl-x. Furthermore, this review highlights aberrant splicing of Bcl-x involved in apoptosis evade, autophagy, metastasis, and therapy resistance of various cancer cells. Last, emphasis is given to the clinical role of targeting Bcl-x splicing correction in human cancer based on the splice-switching oligonucleotides, small molecular modulators and BH3 mimetics. Thus, it is highlighting significance of aberrant splicing isoforms of Bcl-x as targets for cancer therapy.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S13046-021-02001-W
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137268]
专题	中国科学院近代物理研究所
通讯作者	Di,Cuixia; Zhang,Hong
作者单位	1.Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences 2.University of Chinese Academy of Sciences; College of Life Sciences 3.School of Nuclear Science and Technology, University of Chinese Academy of Sciences 4.Medical Genetics Center of Gansu Maternal and Child Health Care Center 5.School of Basic Medical Sciences, Lanzhou University 6.Advanced Energy Science and Technology Guangdong Laboratory 7.Institute of Modern Physics, Chinese Academy of Sciences; Department of Heavy Ion Radiation Medicine, Bio-Medical Research Center
推荐引用方式 GB/T 7714	Dou,Zhihui,Zhao,Dapeng,Chen,Xiaohua,et al. Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation[J]. Journal of Experimental & Clinical Cancer Research,2021,40(1).
APA	Dou,Zhihui.,Zhao,Dapeng.,Chen,Xiaohua.,Xu,Caipeng.,Jin,Xiaodong.,...&Zhang,Hong.(2021).Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation.Journal of Experimental & Clinical Cancer Research,40(1).
MLA	Dou,Zhihui,et al."Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation".Journal of Experimental & Clinical Cancer Research 40.1(2021).