Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma

doi:10.1186/s12885-021-08769-6

	Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma
	Li, Hong-Bin 1; Wang, Jian-Li 2; Jin, Xiao-Dong 3; Zhao, Lei 4; Ye, Hui-Li 4; Kuang, Yan-Bei 3; Ma, Yong 5; Jiang, Xiang-Yan 5; Yu, Ze-Yuan 5
刊名	BMC CANCER
	2021-09-16
卷号	21 期号:1 页码:18
关键词	S100A Pancreatic ductal adenocarcinoma Biomarkers Prognosis Bioinformatics
DOI	10.1186/s12885-021-08769-6
通讯作者	Yu, Ze-Yuan(yuzy17@lzu.edu.cn)
英文摘要	Background Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S100A family have been identified as being involved in cell proliferation, migration and differentiation progression of various cancer types. However, the expression patterns and prognostic values of S100As in PDAC remain to be analyzed. Methods We investigated the transcriptional expressions, methylation level and prognostic value of S100As in PDAC patients from the Oncomine, GEPIA2, Linkedomics and cBioPortal databases. Real-time PCR was used to detect the expressions of S100A2/4/6/10/14/16 in four pancreatic cancer cell lines and pancreatic cancer tissues from PDAC patients undergoing surgery. To verify the results further, immunohistochemistry was used to measure the expression of S100A2/4/6/10/14/16 in 43 PDAC patients' tissue samples. The drug relations of S100As were analyzed by using the Drugbank database. Results The results suggested that, the expression levels of S100A2/4/6/10/14/16 were elevated to PDAC tissues than in normal pancreatic tissues, and the promoter methylation levels of S100A S100A2/4/6/10/14/16 in PDAC (n = 10) were lower compared with normal tissue (n = 184) (P < 0.05). In addition, their expressions were negatively correlated with PDAC patient survival. Conclusions Taken together, these results suggest that S100A2/4/6/10/14/16 might be served as prognostic biomarkers for survivals of PDAC patients.
资助项目	National Natural Science Foundation of China[82003216] ; Fundamental Research Funds for the Central Universities[lzujbky-2017-78]
WOS关键词	CANCER ; BINDING ; PROGRESSION ; PROTEINS
WOS研究方向	Oncology
语种	英语
出版者	BMC
WOS记录号	WOS:000696540700007
资助机构	National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136515]
专题	中国科学院近代物理研究所
通讯作者	Yu, Ze-Yuan
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China 2.Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730030, Peoples R China 4.Lanzhou Univ, Cui Ying Biomed Res Ctr, Hosp 2, Lanzhou 730030, Peoples R China 5.Lanzhou Univ, Hosp 2, Dept Gen Surg, Gansu Prov Canc Hosp, 82 Cui Ying Men, Lanzhou 730030, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Li, Hong-Bin,Wang, Jian-Li,Jin, Xiao-Dong,et al. Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma[J]. BMC CANCER,2021,21(1):18.
APA	Li, Hong-Bin.,Wang, Jian-Li.,Jin, Xiao-Dong.,Zhao, Lei.,Ye, Hui-Li.,...&Yu, Ze-Yuan.(2021).Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma.BMC CANCER,21(1),18.
MLA	Li, Hong-Bin,et al."Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma".BMC CANCER 21.1(2021):18.