Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice

doi:10.1016/j.jff.2021.104779

	Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice
	Xu, Fuqiang 1,3; Li, Qiaoqiao 1,3; Wang, Shuyang 1,2,3; Bai, Jin 1,3; Dong, Miaoyin 1,3; Xiao, Guoqing 1,3; Wang, Junkai 4
刊名	JOURNAL OF FUNCTIONAL FOODS
	2021-12-01
卷号	87 页码:14
关键词	Probiotic Functional foods Lactobacillus casei Heavy ion beams induced-mutagenesis Microbiota Colon cancer
ISSN号	1756-4646
DOI	10.1016/j.jff.2021.104779
通讯作者	Wang, Shuyang(wangsy@impcas.ac.cn) ; Xiao, Guoqing(xiaogq@impcas.ac.cn)
英文摘要	Probiotics, as novel functional foods via microbiota-modulation to enhance host health and inhibit tumor carcinogenesis, have been attracted considerable interests. L. casei JY, as a potential probiotic, was irradiated by 12C6+ beams and a new mutant strain JY300-8 was generated through three round selections of transit tolerance in the upper human gastrointestinal tract, adhesion ability to Caco-2 cells and inhibitory pathogenic microorganisms, respectively. Interestingly, JY300-8 presented excellent properties, including the strongest adhesion ability (86.81%) to Caco-2 cells to our knowledge and more excellent antimicrobial properties, which was used for the potential candidate probiotic. Additionally, JY300-8 could significantly inhibit the proliferation of Caco2, HT29 and HCT116 cells in vitro, respectively. Furthermore, there were better therapeutic effects at an early stage in colon cancer mice, which included the similar survival rates (90%) and stronger inhibitory effect on tumor (83.48%), lower treatment cost and less side effects in comparison to the therapy drug (DFUR) for colon cancer (65.65%), which was attributed to promoting the apoptosis of colon cells and enhancing antitumor response via modulation cancer-induced gut microbiota dysbiosis by oral administration of JY300-8. Therefore, JY300-8 has great potential for bio-prophylactic and bio-therapeutic functional food in colon carcinogenesis. This work provided a promising approach that could improve human health, reduce greatly cancer incidence and mitigate cancer progression via modulation gut microbiota by excellent probiotics intervention.
资助项目	HONGGUANG Special Project of Chinese Academy of Sciences[Y700050YHG] ; National Natural Science Foundation of China[12075294] ; Local Cooperation Project of the Chinese Academy of Sciences[YD-2021-01]
WOS关键词	LACTIC-ACID BACTERIA ; BILE-SALT HYDROLASE ; IN-VITRO ; COLON CARCINOGENESIS ; STRAINS ; PROBIOTICS ; CANCER ; RESISTANCE ; CELLS ; 5-FLUOROURACIL
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000707261400005
资助机构	HONGGUANG Special Project of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Local Cooperation Project of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136228]
专题	中国科学院近代物理研究所
通讯作者	Wang, Shuyang; Xiao, Guoqing
作者单位	1.Univ Chinese Acad Sci, Coll Nucl Sci & Technol, Beijing, Peoples R China 2.Gansu Acad Sci, Inst Biol, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China 4.Northwest Normal Univ, Coll Phys, Anning Rd, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Xu, Fuqiang,Li, Qiaoqiao,Wang, Shuyang,et al. Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice[J]. JOURNAL OF FUNCTIONAL FOODS,2021,87:14.
APA	Xu, Fuqiang.,Li, Qiaoqiao.,Wang, Shuyang.,Bai, Jin.,Dong, Miaoyin.,...&Wang, Junkai.(2021).Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice.JOURNAL OF FUNCTIONAL FOODS,87,14.
MLA	Xu, Fuqiang,et al."Lactobacillus casei JY300-8 generated by (12)C6+beams mutagenesis inhibits tumor progression by modulating the gut microbiota in mice".JOURNAL OF FUNCTIONAL FOODS 87(2021):14.