GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock

doi:10.1038/s41598-017-04524-9

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	GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock
	Cha, Joon-Yung ; Kim, Jeongsik 2; Kim, Tae-Sung ; Zeng, Qingning ; Wang, Lei 1; Lee, Sang Yeol ; Kim, Woe-Yeon ; Somers, David E.
刊名	NATURE COMMUNICATIONS
	2017
卷号	8
ISSN号	2041-1723
DOI	10.1038/s41598-017-04524-9
文献子类	Article
英文摘要	Circadian clock systems help establish the correct daily phasing of the behavioral, developmental, and molecular events needed for the proper coordination of physiology and metabolism. The circadian oscillator comprises transcription-translation feedback loops but also requires post-translational processes that regulate clock protein homeostasis. GIGANTEA is a unique plant protein involved in the maintenance and control of numerous facets of plant physiology and development. Through an unknown mechanism GIGANTEA stabilizes the F-box protein ZEITLUPE, a key regulator of the circadian clock. Here, we show that GIGANTEA has general protein chaperone activity and can act to specifically facilitate ZEITLUPE maturation into an active form in vitro and in planta. GIGANTEA forms a ternary complex with HSP90 and ZEITLUPE and its co-chaperone action synergistically enhances HSP90/HSP70 maturation of ZEITLUPE in vitro. These results identify a molecular mechanism for GIGANTEA activity that can explain its wide-ranging role in plant biology.
学科主题	Science & Technology - Other Topics
出版地	LONDON
WOS关键词	BOX PROTEIN ZEITLUPE ; IN-VITRO ; POSTTRANSLATIONAL REGULATION ; FUNCTIONAL-CHARACTERIZATION ; TARGETED DEGRADATION ; REGULATOR PROTEINS ; SCFZTL COMPLEX ; BLUE-LIGHT ; HSP90 ; THALIANA
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000403874900076
资助机构	National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01GM093285] ; Next-Generation BioGreen21 Program (SSAC)Rural Development Administration (RDA) [PJ01106901] ; Rural Development Administration, Republic of KoreaRural Development Administration (RDA) ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM093285] Funding Source: NIH RePORTER
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/22368]
专题	中科院植物分子生理学重点实验室
作者单位	1.Korea Natl Open Univ, Dept Agr Sci, Seoul 03087, South Korea 2.Kim, Jeongsik; Kim, Tae-Sung; Zeng, Qingning; Wang, Lei; Somers, David E.] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA 3.Gyeongsang Natl Univ, PMBBRC & IALS, Div Appl Life Sci, BK21Plus, Jinju 52828, South Korea 4.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 5.Inst Basic Sci, Ctr Plant Aging Res, Daegu 711873, South Korea
推荐引用方式 GB/T 7714	Cha, Joon-Yung,Kim, Jeongsik,Kim, Tae-Sung,et al. GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock[J]. NATURE COMMUNICATIONS,2017,8.
APA	Cha, Joon-Yung.,Kim, Jeongsik.,Kim, Tae-Sung.,Zeng, Qingning.,Wang, Lei.,...&Somers, David E..(2017).GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock.NATURE COMMUNICATIONS,8.
MLA	Cha, Joon-Yung,et al."GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock".NATURE COMMUNICATIONS 8(2017).