Nanosized HCA-coated borate bioactive glass with improved wound healing effects on rodent model

doi:10.1016/j.cej.2021.130299

	Nanosized HCA-coated borate bioactive glass with improved wound healing effects on rodent model
	Chen, Ruiguo 5,6,7; Li, Qian 6,7,11; Zhang, Qi 12; Xu, Shuai 6,7,8; Han, Jian 6,7,8; Huang, Peiyan 5,6,7; Yu, Zhiwu 6,7; Jia, Daping 2; Liu, Juanjuan 6,7; Jia, Huiling 6,7,8
刊名	CHEMICAL ENGINEERING JOURNAL
	2021-12-15
卷号	426
关键词	Bioactive glass nano-HCA@BG Dynamic immersion Porous structure Wound healing
ISSN号	1385-8947
DOI	10.1016/j.cej.2021.130299
通讯作者	Zhang, Teng(teng_zhang@fzu.edu.cn) ; Ma, Kun(makun@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn)
英文摘要	Borate bioactive glass (BBG) stimulates angiogenesis and promotes cell growth. However, controlling the degradation rate of BBG and maintaining the critical concentration of bioactive ions suitable for cell promotion and differentiation remain great challenges in soft tissue repair. In this study, a novel approach was proposed to produce nanosized CO32- -containing hydroxyapatite (HCA)-coated BBG (nano-HCA@BG). Unlike the previously reported hard-to-degrade hydroxyapatite (HA) coating after static soaking treatment of BBG, the nano-HCA@BG, obtained by dynamically immersing the BBG powder in a flowing buffer, had a porous structure and was surfacecoated with a layer of amorphous HCA, which improved the biocompatibility and retained the biodegradability of BBG. The effects of nano-HCA@BG were evaluated and compared with those of powdered BBG at the cellular and animal levels. The formation of the HCA-coated nanoporous architecture significantly improves biocompatibility, promotes cell growth and proliferation, and is beneficial for wound healing in rodent skin defects.
资助项目	National Natural Science Foundation of China[U1732155] ; National Natural Science Foundation of China[3190110313] ; National Natural Science Foundation of China[U1632274] ; Ministry of Science and Technology of China[2016YFA0400901] ; Doctor Research Fund of Henan University of Technology[2019BS019] ; HighMagnetic Field Laboratory of Anhui Province
WOS关键词	CONTROLLABLE DEGRADATION ; COMPOSITE SCAFFOLDS ; SILICATE 45S5 ; BONE ; HYDROXYAPATITE ; CONVERSION ; CALCIUM ; RAMAN ; BOROSILICATE ; DISSOLUTION
WOS研究方向	Engineering
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000722298200005
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Doctor Research Fund of Henan University of Technology ; HighMagnetic Field Laboratory of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126758]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Teng; Ma, Kun; Wang, Junfeng
作者单位	1.Songshan Lake Mat Lab, Neutron Sci Platform, Dongguan 523808, Guangdong, Peoples R China 2.First Affiliated Hosp Anhui Med Univ, Dept Plast Surg, Hefei 230032, Anhui, Peoples R China 3.East China Normal Univ, Sch Phys & Elect Sci, Shanghai Key Lab Magnet Resonance, Shanghai 200241, Peoples R China 4.Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA 5.Fuzhou Univ, Coll Mat Sci & Engn, Fuzhou 350108, Fujian, Peoples R China 6.Hefei Inst Phys Sci Chinese Acad Sci, High Field Magnet Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Anhui, Peoples R China 7.Chinese Acad Sci, Hefei, Anhui, Peoples R China 8.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 9.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China 10.Anhui Univ, Inst Informat Technol, Hefei 230601, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Chen, Ruiguo,Li, Qian,Zhang, Qi,et al. Nanosized HCA-coated borate bioactive glass with improved wound healing effects on rodent model[J]. CHEMICAL ENGINEERING JOURNAL,2021,426.
APA	Chen, Ruiguo.,Li, Qian.,Zhang, Qi.,Xu, Shuai.,Han, Jian.,...&Wang, Junfeng.(2021).Nanosized HCA-coated borate bioactive glass with improved wound healing effects on rodent model.CHEMICAL ENGINEERING JOURNAL,426.
MLA	Chen, Ruiguo,et al."Nanosized HCA-coated borate bioactive glass with improved wound healing effects on rodent model".CHEMICAL ENGINEERING JOURNAL 426(2021).