NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer

doi:10.3389/fmolb.2021.708052

	NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer
	He, Xiangming 2,3; Gu, Jinping 1; Zou, Dehong 3; Yang, Hongjian 3; Zhang, Yongfang 3; Ding, Yuqing 3; Teng, Lisong 2
刊名	FRONTIERS IN MOLECULAR BIOSCIENCES
	2021-11-02
卷号	8
关键词	metabolomics triple-negative breast cancer metabolic pathway ROC curve NMR spectroscopy
DOI	10.3389/fmolb.2021.708052
通讯作者	Teng, Lisong(lsteng@zju.edu.cn)
英文摘要	Triple-negative breast cancer (TNBC) is the most fatal type of breast cancer (BC). Due to the lack of relevant targeted drug therapy, in addition to surgery, chemotherapy is still the most common treatment option for TNBC. TNBC is heterogeneous, and different patients have an unusual sensitivity to chemotherapy. Only part of the patients will benefit from chemotherapy, so neoadjuvant chemotherapy (NAC) is controversial in the treatment of TNBC. Here, we performed an NMR spectroscopy-based metabolomics study to analyze the relationship between the patients' metabolic phenotypes and chemotherapy sensitivity in the serum samples. Metabolic phenotypes from patients with pathological partial response, pathological complete response, and pathological stable disease (pPR, pCR, and pSD) could be distinguished. Furthermore, we conducted metabolic pathway analysis based on identified significant metabolites and revealed significantly disturbed metabolic pathways closely associated with three groups of TNBC patients. We evaluated the discriminative ability of metabolites related to significantly disturbed metabolic pathways by using the multi-receiver-operating characteristic (ROC) curve analysis. Three significantly disturbed metabolic pathways of glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, and alanine, aspartate, and glutamate metabolism could be used as potential predictive models to distinguish three types of TNBC patients. These results indicate that a metabolic phenotype could be used to predict whether a patient is suitable for NAC. Metabolomics research could provide data in support of metabolic phenotypes for personalized treatment of TNBC.
资助项目	National Natural Science Foundation of China Youth Science Fund Project[21906147] ; Natural Science Foundation of Zhejiang Province, China[LQ18B050003] ; Zhejiang Provincial Medical and Health Science and Technology Program[2020KY489]
WOS关键词	AMINO-ACID-METABOLISM ; HISTAMINE ; TISSUES ; IDENTIFICATION ; METABONOMICS ; CELLS ; SERUM
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000719635900001
资助机构	National Natural Science Foundation of China Youth Science Fund Project ; Natural Science Foundation of Zhejiang Province, China ; Zhejiang Provincial Medical and Health Science and Technology Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126622]
专题	中国科学院合肥物质科学研究院
通讯作者	Teng, Lisong
作者单位	1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Hangzhou, Peoples R China 2.Zhejiang Univ, Affiliated Hosp 1, Sch Med FAHZU, Hangzhou, Peoples R China 3.Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC, Univ Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	He, Xiangming,Gu, Jinping,Zou, Dehong,et al. NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8.
APA	He, Xiangming.,Gu, Jinping.,Zou, Dehong.,Yang, Hongjian.,Zhang, Yongfang.,...&Teng, Lisong.(2021).NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer.FRONTIERS IN MOLECULAR BIOSCIENCES,8.
MLA	He, Xiangming,et al."NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021).