Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

doi:10.3389/fphar.2021.779779

	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
	Huo, Xing-xing 1,2; Wang, Shu-jie 2; Song, Hang 3; Li, Ming-de 1; Yu, Hua 4; Wang, Meng 2; Gong, Hong-xiao 1; Qiu, Xiao-ting 1; Zhu, Yong-fu 1; Zhang, Jian-ye 5,6
刊名	FRONTIERS IN PHARMACOLOGY
	2021-11-25
卷号	12
关键词	RNA modification N 6-methyladenosine N 1-methyladenosine alternative polyadenylation adenosine-to-inosine editing head and neck squamous cell carcinoma immunotherapy
DOI	10.3389/fphar.2021.779779
通讯作者	Zhu, Yong-fu(zyf240@ahtcm.edu.cn) ; Zhang, Jian-ye(jianyez@163.com)
英文摘要	Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor development and inflammation. Adenosine-related RNA modifications have shown to be linked to cancer and may play a role in cancer occurrence and development. To date, there are at least 170 different chemical RNA modifications that modify coding and non-coding RNAs (ncRNAs). These modifications affect RNA stability and transcription efficiency. In this review, we focus on the current understanding of the four major RNA adenosine modifications (N-6-Methyladenosine, N-1-Methyladenosine, Alternative Polyadenylation Modification and A-to-I RNA editing) and their potential molecular mechanisms related to HNSCC development and progression. We also touch on how these RNA modifications affect treatment of HNSCCs.
资助项目	National Natural Science Foundation of China[81802103] ; National Natural Science Foundation of China[81803938] ; Project of High-Level Talents in AHUTCM[2019rcZD001] ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China[2108085Y29] ; Open project of the Key Laboratory of Regenerative Biology, Chinese Academy of Sciences ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine), Zhejiang Chinese Medical University[ZYXZD2019004]
WOS关键词	POLY(A) TAIL LENGTH ; MESSENGER-RNA ; ALTERNATIVE POLYADENYLATION ; METHYLATION REGULATORS ; RETROSPECTIVE ANALYSIS ; M(6)A METHYLATION ; TUMOR-SUPPRESSOR ; METTL3 PROMOTES ; GENE FAMILY ; GENOME-WIDE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000729102900001
资助机构	National Natural Science Foundation of China ; Project of High-Level Talents in AHUTCM ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China ; Open project of the Key Laboratory of Regenerative Biology, Chinese Academy of Sciences ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine), Zhejiang Chinese Medical University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126436]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhu, Yong-fu; Zhang, Jian-ye
作者单位	1.Anhui Univ Chinese Med, Affiliated Hosp 1, Sci Res Dept, Expt Ctr Clin Res, Hefei, Peoples R China 2.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei, Peoples R China 3.Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China 4.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macau, Peoples R China 5.Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou, Peoples R China 6.Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Huo, Xing-xing,Wang, Shu-jie,Song, Hang,et al. Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma[J]. FRONTIERS IN PHARMACOLOGY,2021,12.
APA	Huo, Xing-xing.,Wang, Shu-jie.,Song, Hang.,Li, Ming-de.,Yu, Hua.,...&Zhang, Jian-ye.(2021).Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma.FRONTIERS IN PHARMACOLOGY,12.
MLA	Huo, Xing-xing,et al."Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma".FRONTIERS IN PHARMACOLOGY 12(2021).