A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.

doi:doi.org/10.1371/journal.pone.0217312

	A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.
	Wang X(王雪); Yuejin Wu; Rujing Wang; Yuanyuan Wei; Yuanmiao Gui
刊名	Plos one
	2019-06-07
ISSN号	0218-3390
DOI	doi.org/10.1371/journal.pone.0217312
英文摘要	Protein-protein interactions (PPIs) play an important role in the life activities of organisms. With the availability of large amounts of protein sequence data, PPIs prediction methods have attracted increasing attention. A variety of protein sequence coding methods have emerged, but the training of these methods is particularly time consuming. To solve this issue, we have proposed a novel matrix sequence coding method. Based on deep neural network (DNN) and a novel matrix protein sequence descriptor, we constructed a protein interaction prediction model for predicting PPIs. When performed on human PPIs data, the method achieved an accuracy of 94.34%, a recall of 98.28%, an area under the curve (AUC) of 97.79% and a loss of 23.25%. A non-redundant dataset was used to evaluate this prediction model, and the prediction accuracy is 88.29%. These results indicate that the matrix of sequence (MOS) descriptor can enhance the predictive power of PPIs and reduce training time, which can be a useful complement for future proteomics research. The experimental code and experimental results can be found at https://github.com/smalltalkman/ hppi-tensorflow.
URL标识	查看原文
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126104]
专题	中国科学院合肥物质科学研究院
通讯作者	Yuanmiao Gui
作者单位	Institute of Technical Biology & Agriculture Engineering, Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Wang X,Yuejin Wu,Rujing Wang,et al. A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.[J]. Plos one,2019.
APA	Wang X,Yuejin Wu,Rujing Wang,Yuanyuan Wei,&Yuanmiao Gui.(2019).A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences..Plos one.
MLA	Wang X,et al."A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.".Plos one (2019).