Imaging strategies using cyanine probes and materials for biomedical visualization of live animals

	Imaging strategies using cyanine probes and materials for biomedical visualization of live animals
	Fei, Guiqiang; Ma, Siyue; Wang, Chao; Chen, Tao; Li, Yulin; Liu, Yuxia; Tang, Bo; James, Tony D.; Chen, Guang
刊名	COORDINATION CHEMISTRY REVIEWS
	2021
卷号	447
关键词	In vivo fluorescence imaging Strategies Cyanine Biomedical visualization
英文摘要	In vivo fluorescence imaging provides vital information required for biomedical research in living animals, and as such plays an essential role in disease assessment. Unfortunately, due to the lack of coherent approaches, in vivo fluorescence visualization is challenging, wasting not only time but the animals used. In recent years, cyanine-based systems have been found to exhibit attractive optical properties with appropriate bio-functionality and therefore have become go-to probes for in vivo research. Herein, we collected the recent breakthroughs using cyanine-based systems associated with use in living mammals, to provide researchers with the required information to develop appropriate strategies able to meet the increasing stringent requirements for practical applications. We concentrate on 6 sites within the cyanine skeleton, including the: meso-position (1), N-indole (2), phenyl-indole (2), cyclohexane (1), which have been used to design symmetric or asymmetric cyanine structures. Substitutions at the meso-position provide fluorescence probes featuring a switch of EWG and EDG, PET, spiro-cyclization, ICT within the cyanine skeleton, or FRET, for visualizing analytes in vivo. Substitution at the N-indole forms a positively charged system with long wavelength emission suitable for in vivo imaging. While, modification of the phenyl-indole contributes to the functional properties, including photoacoustic, photothermal and photodynamic behavior, which can be used for multimodal imaging as well as functional imaging in vivo. With a specific trigger at the N-indole or meso-position, NIR fluorescence pro-drugs could be developed for in vivo tracing of the efficiency of drug delivery. While modification of the cyclohexane can introduce a targeting moiety for the accurate monitoring of tumors or organs. Using these strategies appropriate design platforms can be developed to provide the next generation of optical systems for living animal research. Moreover, we hope this review will enable researchers to design systems with high efficiency for in vivo research, which will reduce both the development time and number of animals required to progress the research. (C) 2021 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/60672]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Fei, Guiqiang,Ma, Siyue,Wang, Chao,et al. Imaging strategies using cyanine probes and materials for biomedical visualization of live animals[J]. COORDINATION CHEMISTRY REVIEWS,2021,447.
APA	Fei, Guiqiang.,Ma, Siyue.,Wang, Chao.,Chen, Tao.,Li, Yulin.,...&Chen, Guang.(2021).Imaging strategies using cyanine probes and materials for biomedical visualization of live animals.COORDINATION CHEMISTRY REVIEWS,447.
MLA	Fei, Guiqiang,et al."Imaging strategies using cyanine probes and materials for biomedical visualization of live animals".COORDINATION CHEMISTRY REVIEWS 447(2021).