Tuning cell adhesion on supported lipid bilayers via nanoscale geometry

doi:10.1039/d1sm01407b

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Tuning cell adhesion on supported lipid bilayers via nanoscale geometry
	Li L(李龙)4,5; Gao J 2,3; Shao YF(邵颖峰)4,5; Song F(宋凡)1,4,5; Hu JL 2,3
刊名	SOFT MATTER
	2021-10-20
页码	7
ISSN号	1744-683X
DOI	10.1039/d1sm01407b
通讯作者	Shao, Yingfeng(shaoyf@lnm.imech.ac.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn)
英文摘要	The cell-supported lipid bilayer (SLB) adhesion system has been widely used as the model system to study the receptor-ligand interactions that occur at the membrane interface. The ligand-functionalized SLBs are deposited either directly on solids or on polymer cushions. An important question that arises is whether the geometry of the SLB affects the binding of cell adhesion receptors to the ligands. By using a mesoscopic mechanical model and Monte Carlo simulations, we have investigated the adhesion of a fluid membrane to a corrugated or egg-carton shaped SLB. We find that the nanoscale geometry of the SLB strongly affects the receptor-ligand binding. This effect results from the fact that the adhering membrane bends according to the SLB geometry in order for the adhesion receptors to bind ligands. The membrane bending couples with spatial distribution of the receptor-ligand complexes and membrane thermal undulations. Our results demonstrate that cell adhesion to SLBs can be controlled by tuning the nanoscale geometry of the SLB, and may have profound implications for future development of tissue engineering and regenerative medicine.
分类号	二类
资助项目	National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[21504038] ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
WOS关键词	MEMBRANE-ANCHORED RECEPTORS ; BINDING ; KINETICS ; LIGANDS ; CONSTANTS ; ANTIGEN ; RAFTS ; SELF
WOS研究方向	Chemistry ; Materials Science ; Physics ; Polymer Science
语种	英语
WOS记录号	WOS:000715423600001
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences
其他责任者	Shao, Yingfeng ; Hu, Jinglei
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/87895]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 2.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China; 3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China; 4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China; 5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China;
推荐引用方式 GB/T 7714	Li L,Gao J,Shao YF,et al. Tuning cell adhesion on supported lipid bilayers via nanoscale geometry[J]. SOFT MATTER,2021:7.
APA	李龙,Gao J,邵颖峰,宋凡,&Hu JL.(2021).Tuning cell adhesion on supported lipid bilayers via nanoscale geometry.SOFT MATTER,7.
MLA	李龙,et al."Tuning cell adhesion on supported lipid bilayers via nanoscale geometry".SOFT MATTER (2021):7.