Study on the Influence of Rhizome Zingiberis on the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry

	Study on the Influence of Rhizome Zingiberis on the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry
	Xin Y ; Pi ZF ; Song FR ; Liu ZQ ; Liu SY
刊名	acta chimica sinica
	2012
卷号	70 期号:5 页码:551-560
关键词	MODEL
ISSN号	0567-7351
通讯作者	xin y
中文摘要	everted rat gut sac model was used to carry out the experiments about detoxification mechanism of rhizoma zingiberis on the diester-aconite alkaloids in radix aconiti. all the diester-aconite alkaloids were detected by waters ultra performance liquid chromatography coupled with triple quadrupole mass spectrometry. content of aconitine, mesaconitine and hypaconitine were calculated by standard curve method and other diester-aconite alkaloids were calculated by peak area. results showed that the accumulative absorptive content of aconitine, mesaconitine, hypaconitine and the peak area of 10-oh-mesaconitine in unit area of the rat gut sac decreased when the extract of rhizoma zingiberis was added into k-r solution contained the exact of radix aconiti, and that increased when verapamil was added into k-r solution contained the exact of radix aconiti, which indicated the diester-aconite alkaloids might be the potential substrate of p-glycoprotein (p-gp). the accumulative content of digoxin in unit area of the rat gut sac decreased when the extract of rhizoma zingiberis was added into the intestinal nutritious solution contained digoxin, which indicated the extract of rhizoma zingiberis might be the revulsant of p-glycoprotein. on the basis of the above results, it could be concluded that the possible mechanism of the inhibition of the extract of rhizoma zingiberis on the absorption of the aconite alkaloids in the rat gut sacs was the extract of rhizoma zingiberis which served as the potential revulsant could inhibit the absorption of aconite alkaloids by inhibiting the activity of the intestinal p-gp.
收录类别	SCI收录期刊论文
语种	中文
WOS记录号	WOS:000302840600005
公开日期	2013-10-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48843]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xin Y,Pi ZF,Song FR,et al. Study on the Influence of Rhizome Zingiberis on the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry[J]. acta chimica sinica,2012,70(5):551-560.
APA	Xin Y,Pi ZF,Song FR,Liu ZQ,&Liu SY.(2012).Study on the Influence of Rhizome Zingiberis on the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry.acta chimica sinica,70(5),551-560.
MLA	Xin Y,et al."Study on the Influence of Rhizome Zingiberis on the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry".acta chimica sinica 70.5(2012):551-560.