Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis

doi:10.1021/acs.orglett.1c01601

	Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis
	Chen, Zi-Hui 1,2; Li, Wang-Sheng 1,3; Zhang, Zai-Yong 1; Luo, Hui 3; Wang, Jian-Rong 1; Zhang, Hai-Yan 4; Zeng, Zi-Rong 1; Chen, Bao 1; Li, Xu-Wen 1,2; Guo, Yue-Wei 1,2
刊名	ORGANIC LETTERS
	2021-08-06
卷号	23 期号:15 页码:5621-5625
ISSN号	1523-7060
DOI	10.1021/acs.orglett.1c01601
通讯作者	Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A novel norditerpenoid, sinusiaetone A (1), featuring an uncommon bicyclo[11.3.0]hexadecane carbon skeleton, and four polyoxygenated cembranoids (2-5) were isolated from the Hainan soft coral Sinularia siaesensis. Their structures were established by spectroscopic analysis, X-ray diffraction, quantum chemical computational approaches, and/or a modified Mosher's method. A plausible biosynthetic pathway of 1 and its biogenetic relationship with 2-5 were proposed. New compounds 1-3 displayed an interesting inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells.
资助项目	National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; National Key Research and Development Program of China[2018YFC0310903] ; Shanghai RisingStar Program[20QA1411100] ; Youth Innovation Promotion Association of CAS[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS关键词	DITERPENOIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000684033200006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298073]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Hai-Yan; Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang 524023, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zi-Hui,Li, Wang-Sheng,Zhang, Zai-Yong,et al. Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis[J]. ORGANIC LETTERS,2021,23(15):5621-5625.
APA	Chen, Zi-Hui.,Li, Wang-Sheng.,Zhang, Zai-Yong.,Luo, Hui.,Wang, Jian-Rong.,...&Guo, Yue-Wei.(2021).Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis.ORGANIC LETTERS,23(15),5621-5625.
MLA	Chen, Zi-Hui,et al."Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis".ORGANIC LETTERS 23.15(2021):5621-5625.