Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii

doi:10.1016/j.fitote.2021.104959

	Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii
	Zong, Jian-Fa 1; Zhang, Meng-Meng 2; Zhou, Yu-Bo 2; Li, Jia 2; Hou, Ai-Jun 1; Lei, Chun 1
刊名	FITOTERAPIA
	2021-09-01
卷号	153 页码:5
关键词	Hypericum forrestii (Chittenden) N Robson Clusiaceae Acylphloroglucinol meroterpenoid Hyperiforins A-C Protein tyrosine phosphatase 1B
ISSN号	0367-326X
DOI	10.1016/j.fitote.2021.104959
通讯作者	Hou, Ai-Jun(ajhou@shmu.edu.cn) ; Lei, Chun(chunlei@fudan.edu.cn)
英文摘要	Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 +/- 2.40 to 14.21 +/- 3.51 is mu M.
资助项目	National Natural Science Foundation of China[21672040] ; National Natural Science Foundation of China[82073717] ; Science and Technology Commission of Shanghai Municipality[20S21900600]
WOS关键词	A-H ; DERIVATIVES ; PHLOROGLUCINOL ; HYPERFORIN ; SKELETON ; ANALOGS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000684861800009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297943]
专题	中国科学院上海药物研究所
通讯作者	Hou, Ai-Jun; Lei, Chun
作者单位	1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zong, Jian-Fa,Zhang, Meng-Meng,Zhou, Yu-Bo,et al. Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii[J]. FITOTERAPIA,2021,153:5.
APA	Zong, Jian-Fa,Zhang, Meng-Meng,Zhou, Yu-Bo,Li, Jia,Hou, Ai-Jun,&Lei, Chun.(2021).Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii.FITOTERAPIA,153,5.
MLA	Zong, Jian-Fa,et al."Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii".FITOTERAPIA 153(2021):5.