Metal-organic frameworks for advanced drug delivery

doi:10.1016/j.apsb.2021.03.019

	Metal-organic frameworks for advanced drug delivery
	He, Siyu 1,2; Wu, Li 1; Li, Xue 3; Sun, Hongyu 1; Xiong, Ting 1,4; Liu, Jie 5; Huang, Chengxi 1,2; Xu, Huipeng 1; Sun, Huimin 6; Chen, Weidong 5
刊名	ACTA PHARMACEUTICA SINICA B
	2021-08-01
卷号	11 期号:8 页码:2362-2395
关键词	Metal-organic frameworks Drug loading Drug delivery systems Synthesis and characterization Diseases therapy Pharmaceutics Biopharmaceutics Biosafety
ISSN号	2211-3835
DOI	10.1016/j.apsb.2021.03.019
通讯作者	Chen, Weidong(anzhongdong@126.com) ; Gref, Ruxandra(ruxandra.gref@u-psud.fr) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
资助项目	National Key R&D Program of China[2020YFE0201700] ; National Nature Science Foundation of China[81773645] ; French National Research Agency (ANR), France (France)[ANR-10-LABX-0035]
WOS关键词	ONE-POT SYNTHESIS ; ZEOLITIC IMIDAZOLATE FRAMEWORKS ; ROOM-TEMPERATURE SYNTHESIS ; SOLVENT-FREE SYNTHESIS ; CONTROLLED-RELEASE ; MOF NANOPARTICLES ; MICROWAVE SYNTHESIS ; MAGNETIC-RESONANCE ; CD-MOF ; COORDINATION POLYMERS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000692095800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297795]
专题	中国科学院上海药物研究所
通讯作者	Chen, Weidong; Gref, Ruxandra; Zhang, Jiwen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Paris Saclay, Inst Sci Mol Orsay, F-91400 Orsay, France 4.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Chinese Med Preparat, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China 5.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230012, Peoples R China 6.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	He, Siyu,Wu, Li,Li, Xue,et al. Metal-organic frameworks for advanced drug delivery[J]. ACTA PHARMACEUTICA SINICA B,2021,11(8):2362-2395.
APA	He, Siyu.,Wu, Li.,Li, Xue.,Sun, Hongyu.,Xiong, Ting.,...&Zhang, Jiwen.(2021).Metal-organic frameworks for advanced drug delivery.ACTA PHARMACEUTICA SINICA B,11(8),2362-2395.
MLA	He, Siyu,et al."Metal-organic frameworks for advanced drug delivery".ACTA PHARMACEUTICA SINICA B 11.8(2021):2362-2395.