Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives

doi:10.1021/acs.orglett.0c04099

	Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives
	Chen, Jian-Ping 1; Li, Yi 1; Liu, Chao 2,3; Wang, Tianyi 1,2,3; Chung, Lung Wa 2,3; Xu, Ming-Hua 1,2,3
刊名	ORGANIC LETTERS
	2021-01-15
卷号	23 期号:2 页码:571-577
ISSN号	1523-7060
DOI	10.1021/acs.orglett.0c04099
通讯作者	Xu, Ming-Hua(xumh@sustech.edu.cn)
英文摘要	A highly enantioselective rhodium-catalyzed intermolecular hydroarylation of alpha-aminoalkyl acrylates using water as a direct proton source has been realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of alpha-aryl-methyl-substituted beta(2)-, gamma(2)-, and delta(2)-amino esters with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions. By utilizing this method, a series of structurally interesting benzo-fused heterocyclic molecules and the corresponding beta(2)-, gamma(2)-, and delta(2)-amino acids are facilely constructed.
资助项目	National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; National Natural Science Foundation of China[21971103] ; National Natural Science Foundation of China[21672229] ; National Natural Science Foundation of China[81521005] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
WOS关键词	CHIRAL DIENE LIGANDS ; ADDITION-ENANTIOSELECTIVE PROTONATION ; CONJUGATE ADDITION ; AMINO-ACIDS ; BETA(2)-AMINO ACIDS ; EFFICIENT ACCESS ; STEREOSELECTIVE-SYNTHESIS ; MICHAEL ADDITION ; OLEFIN LIGANDS ; BETA-PEPTIDES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000643163800058
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297401]
专题	中国科学院上海药物研究所
通讯作者	Xu, Ming-Hua
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Dept Chem, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Chen, Jian-Ping,Li, Yi,Liu, Chao,et al. Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives[J]. ORGANIC LETTERS,2021,23(2):571-577.
APA	Chen, Jian-Ping,Li, Yi,Liu, Chao,Wang, Tianyi,Chung, Lung Wa,&Xu, Ming-Hua.(2021).Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives.ORGANIC LETTERS,23(2),571-577.
MLA	Chen, Jian-Ping,et al."Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives".ORGANIC LETTERS 23.2(2021):571-577.