beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery

doi:10.1016/j.ijpharm.2021.120602

	beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery
	Singh, Parbeen 1,2,3; Chen, Yongli 1,2; Tyagi, Deependra 4; Wu, Li 3; Ren, Xiaohong 3; Feng, Jinglong 1; Carrier, Andrew 5,6; Luan, Tiangang 2; Tang, Yongjun 1; Zhang, Jiwen 3,7
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2021-06-01
卷号	602 页码:10
关键词	Targeted drug delivery Supramolecular polymer Hyaluronic acid-cyclodextrin pH-responsive drug release
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2021.120602
通讯作者	Tang, Yongjun(tangyongjun@szpt.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Zhang, Xu(Xu_Zhang@cbu.ca)
英文摘要	13-Cyclodextrin (13-CD) was grafted onto hyaluronic acid (HA) in a single step to generate a supramolecular biopolymer (HA-13-CD) that was explored for targeted drug delivery applications. Along with its excellent biocompatibility, the prepared HA-13-CD exhibits not only exceptionally high loading capacity for the model drugs doxorubicin and Rhodamine B through the formation of inclusion complexes with the 13-CD component, but also the capability of targeted drug delivery to cancerous cells with a high level of expression of CD44 receptors, attributable to its HA component. The polymer can release the drug under slightly acidic conditions. With all its attributes, HA-13-CD may be a promising cancer-cell-targeting drug carrier.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Science and Technology Major Project[2017ZX09101001006] ; Postdoctoral Foundation Project of Shenzhen Polytechnic[6019330006K] ; Postdoctoral Foundation Project of Shenzhen Polytechnic[6019330007K] ; Shenzhen Science and Technology Program[GJHZ20180928161212140] ; Cape Breton University RISE program ; NSERC ; Canada Research Chairs program
WOS关键词	TUMOR ; BIOMATERIALS ; COMPLEX ; BINDING ; PH
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000659060400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297088]
专题	中国科学院上海药物研究所
通讯作者	Tang, Yongjun; Zhang, Jiwen; Zhang, Xu
作者单位	1.Shenzhen Polytech, Shenzhen Key Lab Fermentat Purificat & Anal, Dept Biol Appl Engn, Postdoctoral Innovat Practice Base, Shenzhen 518055, Peoples R China 2.Sun Yat Sen Univ, Sch Marine Sci, State Key Lab Biocontrol, Guangzhou 51027, Peoples R China 3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Shenzhen Univ, Sch Basic Med Sci, Sch Med, Shenzhen 518060, Guangdong, Peoples R China 5.Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 6.Cape Breton Univ, Dept Hlth Sci, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada 7.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Singh, Parbeen,Chen, Yongli,Tyagi, Deependra,et al. beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2021,602:10.
APA	Singh, Parbeen.,Chen, Yongli.,Tyagi, Deependra.,Wu, Li.,Ren, Xiaohong.,...&Zhang, Xu.(2021).beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery.INTERNATIONAL JOURNAL OF PHARMACEUTICS,602,10.
MLA	Singh, Parbeen,et al."beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery".INTERNATIONAL JOURNAL OF PHARMACEUTICS 602(2021):10.