Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses

doi:10.1038/s41598-021-92371-0

	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
	Khosroshahi, Siamak Farajzadeh 2; Yin, Xianzhen 1; Donat, Cornelius K.3,5; McGarry, Aisling 3; Lopez, Maria Yanez 3; Baxan, Nicoleta 4; Sharp, David J.3; Sastre, Magdalena 3; Ghajari, Mazdak 2
刊名	SCIENTIFIC REPORTS
	2021-06-21
卷号	11 期号:1 页码:12
ISSN号	2045-2322
DOI	10.1038/s41598-021-92371-0
通讯作者	Khosroshahi, Siamak Farajzadeh(s.f.khosroshahi@imperial.ac.uk)
英文摘要	Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood-brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention.
资助项目	Wellcome Trust[212430/Z/18/Z] ; Wellcome Trust Networks of Excellence ; Royal British Legion Centre for Blast Injury Studies, Imperial College London
WOS关键词	TRAUMATIC BRAIN-INJURY ; HEAD-INJURY ; BARRIER ; IMPACT ; DISRUPTION ; INFLAMMATION ; DEFORMATION ; NEUROTRAUMA ; CORTEX ; DAMAGE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000667261900015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296871]
专题	中国科学院上海药物研究所
通讯作者	Khosroshahi, Siamak Farajzadeh
作者单位	1.Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Imperial Coll London, Dyson Sch Design Engn, London, England 3.Imperial Coll London, Dept Brain Sci, London, England 4.Imperial Coll London, Biol Imaging Ctr, London, England 5.Imperial Coll London, Ctr Blast Injury Studies, London, England
推荐引用方式 GB/T 7714	Khosroshahi, Siamak Farajzadeh,Yin, Xianzhen,Donat, Cornelius K.,et al. Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses[J]. SCIENTIFIC REPORTS,2021,11(1):12.
APA	Khosroshahi, Siamak Farajzadeh.,Yin, Xianzhen.,Donat, Cornelius K..,McGarry, Aisling.,Lopez, Maria Yanez.,...&Ghajari, Mazdak.(2021).Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.SCIENTIFIC REPORTS,11(1),12.
MLA	Khosroshahi, Siamak Farajzadeh,et al."Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses".SCIENTIFIC REPORTS 11.1(2021):12.