Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

doi:10.1039/d1sc02154k

	Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy
	Dou, Wei-Tao 1,2; Xu, Fugui 3; Xu, Chen-Xi 1,2,4; Gao, Jie 1,2,4; Ru, Hong-Bo 4; Luan, Xiangfeng 3; Zhang, Jiacheng 3; Zhu, Ling 1,2,4; Sedgwick, Adam C.5; Chen, Guo-Rong 1,2
刊名	CHEMICAL SCIENCE
	2021-07-15
页码	9
ISSN号	2041-6520
DOI	10.1039/d1sc02154k
通讯作者	Li, Jia(jli@simm.ac.cn) ; Mai, Yiyong(mai@sjtu.edu.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要	Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and alpha(v)beta(3) integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged alpha(v)beta(3) integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy.
资助项目	National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; National Natural Science Foundation of China[21774076] ; National Natural Science Foundation of China[21776078] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; Program of Shanghai Academic Research Leader[19XD1421700] ; Fundamental Research Funds for the Central Universities[222201717003] ; National Postdoctoral Program for Innovative Talents[BX20190115] ; Shanghai Post-doctoral Excellence Program[2019044] ; China Postdoctoral Science Foundation[2020M681206] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01]
WOS关键词	NEGATIVE BREAST-CANCER ; ALPHA(V)BETA(3) ; DELIVERY ; SYSTEMS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000675565100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296775]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; Mai, Yiyong; He, Xiao-Peng
作者单位	1.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, 130 Meilong RD, Shanghai 200237, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai Key Lab Elect Insulat & Thermal Ageing, 800 Dongchuan RD, Shanghai 200240, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 5.Univ Texas Austin, Dept Chem, Austin, TX 78712 USA 6.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 7.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Dou, Wei-Tao,Xu, Fugui,Xu, Chen-Xi,et al. Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy[J]. CHEMICAL SCIENCE,2021:9.
APA	Dou, Wei-Tao.,Xu, Fugui.,Xu, Chen-Xi.,Gao, Jie.,Ru, Hong-Bo.,...&He, Xiao-Peng.(2021).Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy.CHEMICAL SCIENCE,9.
MLA	Dou, Wei-Tao,et al."Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy".CHEMICAL SCIENCE (2021):9.