In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model

doi:10.1016/j.mtcomm.2020.101727

CORC > 金属研究所 > 中国科学院金属研究所

	In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model
	Wang, Haijian 1; Kumazawa, Takashi 1; Zhang, Ying 1; Wang, Haiwei 2,3; Ju, Dongying 1,4,5
刊名	MATERIALS TODAY COMMUNICATIONS
	2021-03-01
卷号	26 页码:12
关键词	Mg-RE sheet In vivo Amorphous Degradable Bone response
ISSN号	2352-4928
DOI	10.1016/j.mtcomm.2020.101727
通讯作者	Ju, Dongying(dyju@sit.ac.jp)
英文摘要	A new type of Mg-rare earth (Ce, La) and the AZ31 alloy sheets were prepared by vertical twin-roll casting (TRC) technology under identical casting conditions, and their microstructural features, degradation behaviours and bone responses were investigated. The microstructural characterization showed that the Mg-RE (rare earth) exhibited a higher amorphous forming ability than the AZ31. Moreover, the results of electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization indicated that the Mg-RE sheets displayed a higher corrosion resistance compared with the AZ31 sheets. Additionally, the Ti, Mg-RE and AZ31 sheet implants were immobilized and implanted in a rat femur model to observe degradation behavior during 16 weeks. in vivo tests showed that no significant change in the femur surrounding the Ti group, which excluded the external factor that the new bone formation resulting from bone remodeling. Furthermore, the Mg-RE group induced more newly formed bones, which met the necessary conditions for the prevention of pathological fractures. Therefore, the novel Mg-RE alloy appear to hold a healing candidate as the biodegradable implant material.
资助项目	High-Tech Research Center and Animal experiment Project[2019-5]
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000634334200002
资助机构	High-Tech Research Center and Animal experiment Project
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/161959]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ju, Dongying
作者单位	1.Saitama Inst Technol, Dept High Tech Res Ctr, Fusaiji 1690, Fukaya 3690293, Japan 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China Hefei, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 4.Univ Sci & Technol Liaoning, Sch Mat & Met, Anshan 114051, Peoples R China 5.Ningbo Haizhi Inst Mat Ind Innovat, Ningbo 315000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Haijian,Kumazawa, Takashi,Zhang, Ying,et al. In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model[J]. MATERIALS TODAY COMMUNICATIONS,2021,26:12.
APA	Wang, Haijian,Kumazawa, Takashi,Zhang, Ying,Wang, Haiwei,&Ju, Dongying.(2021).In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model.MATERIALS TODAY COMMUNICATIONS,26,12.
MLA	Wang, Haijian,et al."In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model".MATERIALS TODAY COMMUNICATIONS 26(2021):12.