MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

CORC > 金属研究所 > 中国科学院金属研究所

	MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway
	Cheng Du 1; Xiaomin Yi 2; Wenchao Liu 2; Tao Han 1; Zhaozhe Liu 1; Zhenyu Ding 1; Zhendong Zheng 1; Ying Piao 1; Jianlin Yuan 2; Yaling Han 1
刊名	BMC Cancer
	2014
卷号	14 期号:1
ISSN号	1471-2407
英文摘要	Trastuzumab resistance is almost inevitable in the management of human epidermal growth factor receptor (HER) 2 positive breast cancer, in which phosphatase and tensin homolog deleted from chromosome 10 (PTEN) loss is implicated. Since metadherin (MTDH) promotes malignant phenotype of breast cancer, we sought to define whether MTDH promotes trastuzumab resistance by decreasing PTEN expression through an NFκB-dependent pathway.
语种	英语
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/159389]
专题	金属研究所_中国科学院金属研究所
作者单位	1.Institute of Metal Research, Chinese Academy of Sciences 2.中国人民解放军第四军医大学 3.Department of Urology
推荐引用方式 GB/T 7714	Cheng Du,Xiaomin Yi,Wenchao Liu,et al. MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway[J]. BMC Cancer,2014,14(1).
APA	Cheng Du.,Xiaomin Yi.,Wenchao Liu.,Tao Han.,Zhaozhe Liu.,...&Xiaodong Xie.(2014).MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway.BMC Cancer,14(1).
MLA	Cheng Du,et al."MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway".BMC Cancer 14.1(2014).