In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院饮用水科学与技术重点实验室

	In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages
	Li, Xinyan; Li, Na; Rao, Kaifeng; Huang, Qinghui; Ma, Mei
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2020-07-21
卷号	54 期号:14 页码:8900-8908
ISSN号	0013-936X
英文摘要	Scarce attention has been paid to the immunotoxicity of organophosphate flame retardants (PFRs), which poses a challenge to the systematic assessment of their health risks. In this study, a battery of in vitro immunotoxicity screening assays, including adhesion, phagocytosis, and 48 cytokine/chemokine production, was measured after exposing THP-1-derived macrophages to six selected common PFRs (TPHP, TDCPP, TNBP, TOCP, TCEP, and TBOEP) at a noncytotoxic concentration (<= 50 mu M). Our results showed that TPHP and TBOEP partially attenuated the adhesion and phagocytosis of the THP-1 m phi s and that TDCPP caused a functional loss of phagocytosis, implying the potential immunosuppression. In contrast, TNBP and TOCP may cause an immunostimulation by significantly promoting cell adhesion and enhancing phagocytic efficiency. Additionally, the results from a cytokine/chemokine secretion analysis revealed the proinflammatory properties of TDCPP, TPHP, and TBOEP. TOCP was thought to disrupt the inflammatory balance by inhibiting both proinflammatory and antiinflammatory cytokines. TCEP showed no effect on adhesion or phagocytosis and little modulation of cytokine release at this experimental concentration. Overall, this study supports that PFRs can be immunotoxic to macrophages in different ways and provides evidence for developing more sensitive in vitro immunotoxicity bioassay methods.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/45311]
专题	生态环境研究中心_中国科学院饮用水科学与技术重点实验室
推荐引用方式 GB/T 7714	Li, Xinyan,Li, Na,Rao, Kaifeng,et al. In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(14):8900-8908.
APA	Li, Xinyan,Li, Na,Rao, Kaifeng,Huang, Qinghui,&Ma, Mei.(2020).In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(14),8900-8908.
MLA	Li, Xinyan,et al."In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.14(2020):8900-8908.