Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets
	Sun, Zhendong; Tang, Zhi; Yang, Xiaoxi; Liu, Qian S.; Liang, Yong; Fiedler, Heidelore; Zhang, Jianqing; Zhou, Qunfang; Jiang, Guibin
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2020-02-10
卷号	703 页码:1-9
关键词	3-tert-Butyl-4-hydroxyanisole Food additive Obesity Adipogenesis Lipid metabolism
ISSN号	0048-9697
英文摘要	As one of the widely used anthropogenic food additives, 3-tert-butyl-4-hydroxyanisole (3-BHA) has been found to perturb adipogenesis in vitro and induce lipid accumulation in some strains of oleaginous microalgae. The impact of this chemical on adipocyte development and lipid metabolism in mammals remains to be elucidated. In this study, we performed 18-week oral administration of 3-BHA to male C57BL/6J mice with normal diet (ND) or high-fat diet (HFD) and investigated its impacts on adipogenesis and lipid accumulation in vivo. The results indicated that long-term exposure to 3-BHA impacted the mouse body weight gain, white adipose tissue accumulation, and plasma lipids through transcriptional regulation of adipogenesis, lipid metabolism, and adipocyte endocrine function, while glucose metabolism and insulin sensitivity remained unaffected. HFD-fed mice responded to 3-BHA stimulation differently from ND-fed animals, suggesting potential risks for the human burden of 3-BHA in lean and obese subjects. The findings herein validate 3-BHA as an environmental obesogen, and more caution is recommended for its authorized use as a food antioxidant against lipid rancidity. (C) 2019 Published by Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44772]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Sun, Zhendong,Tang, Zhi,Yang, Xiaoxi,et al. Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,703:1-9.
APA	Sun, Zhendong.,Tang, Zhi.,Yang, Xiaoxi.,Liu, Qian S..,Liang, Yong.,...&Jiang, Guibin.(2020).Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets.SCIENCE OF THE TOTAL ENVIRONMENT,703,1-9.
MLA	Sun, Zhendong,et al."Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets".SCIENCE OF THE TOTAL ENVIRONMENT 703(2020):1-9.