Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies
	Feng, Hongru; Cao, Huiming; Li, Juan; Zhang, Haiyan; Xue, Qiao; Liu, Xian; Zhang, Aiqian; Fu, Jianjie
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2020-07-20
卷号	727 页码:1-11
关键词	Endocrine disruption Environmental contamination Estrogen receptor MVLN assay Molecular docking and dynamics simulation
ISSN号	0048-9697
英文摘要	Benzotriazole UV stabilizers (BUVs) are used in a variety of products to prevent yellowing and degradation. However, knowledge of the estrogenic activity of BUVs is still lacking. In the present study, a strategy combining in vitro assays and computational studies was adopted to evaluate the estrogenic activity of BUVs. 2-(2-Hydroxy-5-methlphenyl) benzotriazole (UV-P), 2-(5-tert-butyl-2-hydroxyphenyl)benzotriazole (UV-PS), and 2-(3-Allyl-2-hydroxy-5-methylphenyl)-2H-benzotriazole (UV-9) induced partial estrogenic activity while 2-(2-hydroxy-5-tert-octyl-phenyl)benzotriazole (UV-329), 2-(3-s-butyl-5-tert-butyl-2-hydroxyphenyl)benzotriazole (UV-350), and 3-(2H-benzotriazolyl)-5- (1,1-di-methylethyl)-4-hydroxy-benzene-propanoic acid octyl esters (UV-384) showed no estrogenic activity in MVLN assays. The results of in vitro assays were in accord with the results of computational studies. Moreover, ICI 182,780 suppressed the estrogenic activity of BUVs both in the absence and presence of E-2, demonstrating that the estrogen responsive element (ERE) transcription activities of BUVs are generated through an estrogen receptor (ER) mediated pathway. Our findings suggest that the endocrine disruption effects of BUVs are a cause for concern. (C) 2020 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44678]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Feng, Hongru,Cao, Huiming,Li, Juan,et al. Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,727:1-11.
APA	Feng, Hongru.,Cao, Huiming.,Li, Juan.,Zhang, Haiyan.,Xue, Qiao.,...&Fu, Jianjie.(2020).Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies.SCIENCE OF THE TOTAL ENVIRONMENT,727,1-11.
MLA	Feng, Hongru,et al."Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies".SCIENCE OF THE TOTAL ENVIRONMENT 727(2020):1-11.