Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure
	Zhang, Jingxu; Zhou, Qunfang; Su, Ruijun; Sun, Zhendong; Zhang, Weifang; Jin, Xiaoting; Zheng, Yuxin
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2020-06-15
卷号	721 页码:1-16
关键词	PM2.5 Seasonal variation Cardiac function Metabolic remodeling
ISSN号	0048-9697
英文摘要	Increasing epidemiological evidences have revealed the association between ambient fine particulate matter (PM2.5) pollution and cardiovascular disease's morbidity and mortality. However, how seasonal PM2.5 exposure influence cardiac function and the underlying mechanism converged in energy metabolic remodeling remain to be elucidated. This study focused on seasonal PM2.5-induced cardiac dysfunction and metabolic remodeling, and the toxicity differences of PM2.5 samples from different sampling seasons and different exposure dosages were discussed. The results showed that seasonal haze caused cardiac dysfunctions, including decreases in heart rate (HR) and heart rate variability (HRV), abnormal changes in hemodynamic and echocardiographic parameters. Concurrently, the energy production in myocardial tissues was evidently disturbed. In particular, low dose of PM2.5 exposure notably induced the elevation of beta oxidation (beta-oxidation) and tricarboxylic acid cycle (TCA cycle) as the compensation for the disturbed energy metabolism in animals, whereas high dose of PM2.5 exposure attenuated this process and the glycolysis levels were strikingly promoted, thus causing the reduced energy production and cardiac dysfunction. Comparatively, winter PM2.5 exposure caused more severe cardiac toxicity than did summer haze samples, possibly due to the existence of different components and pollutant levels in seasonal hazes. The findings on seasonal PM2.5 induced cardiac dysfunction and myocardial metabolic remodeling provided new insights into cardiovascular disease risks from haze exposure. (C) 2020 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44627]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Jingxu,Zhou, Qunfang,Su, Ruijun,et al. Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,721:1-16.
APA	Zhang, Jingxu.,Zhou, Qunfang.,Su, Ruijun.,Sun, Zhendong.,Zhang, Weifang.,...&Zheng, Yuxin.(2020).Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure.SCIENCE OF THE TOTAL ENVIRONMENT,721,1-16.
MLA	Zhang, Jingxu,et al."Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure".SCIENCE OF THE TOTAL ENVIRONMENT 721(2020):1-16.