Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

	Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation
	Xu, Hong-Bo 1,2,3; Zhang, Ru-Fang 2,3; Luo, Dan 1; Zhou, Yuan 4; Wang, Ying 1,2,3; Fang, Liang 3; Li, Wen-Juan 2,3; Mu, Jun 1,2,3; Zhang, Lihua 4; Zhang, Yukui 4
刊名	international journal of neuropsychopharmacology
	2012-11-01
卷号	15 期号:10 页码:1413-1425
关键词	Biomarker iTRAQ major depressive disorder plasma proteomics
通讯作者	谢鹏
产权排序	4,4
英文摘要	major depressive disorder is a common neuropsychiatric disorder contributing to several socio-economic burdens including disability and suicide. as the underlying pathophysiology of major depressive disorder remains unclear, no objective test is yet available for aiding diagnosis or monitoring disease progression. to contribute to a better understanding of its pathogenesis, a comparative proteomic study was performed to identify proteins differentially expressed in plasma samples obtained from first-onset, treatment-naive depressed patients as compared to healthy controls. samples from the two groups were immunodepleted of seven high-abundance proteins, labelled with isobaric tags for relative and absolute quantitation and then analysed by multi-dimensional liquid chromatography-tandem mass spectrometry. the proteomic results were further validated by immunoblotting or enzyme-linked immunoadsorbent assays and analysed with the metacore database. the results demonstrate that the functions of the altered proteins are primarily involved in lipid metabolism and immunoregulation. these findings suggest that early perturbation of lipid metabolism and immunoregulation may be involved in the pathophysiology of major depressive disorder.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	clinical neurology ; neurosciences ; pharmacology & pharmacy ; psychiatry
研究领域[WOS]	neurosciences & neurology ; pharmacology & pharmacy ; psychiatry
关键词[WOS]	d-binding protein ; apob/apoa-i ratio ; apolipoprotein-b ; cardiovascular-disease ; ceruloplasmin levels ; cerebrospinal-fluid ; biomarkers ; stroke ; schizophrenia ; lipoproteins
收录类别	SCI
语种	英语
WOS记录号	WOS:000309740200005
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/118292]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China 2.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China 3.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Xu, Hong-Bo,Zhang, Ru-Fang,Luo, Dan,et al. Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation[J]. international journal of neuropsychopharmacology,2012,15(10):1413-1425.
APA	Xu, Hong-Bo.,Zhang, Ru-Fang.,Luo, Dan.,Zhou, Yuan.,Wang, Ying.,...&Xie, Peng.(2012).Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation.international journal of neuropsychopharmacology,15(10),1413-1425.
MLA	Xu, Hong-Bo,et al."Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation".international journal of neuropsychopharmacology 15.10(2012):1413-1425.