Protein-imprinted materials: rational design, application and challenges
Yang, Kaiguang; Zhang, Lihua; Liang, Zhen; Zhang, Yukui
刊名analytical and bioanalytical chemistry
2012-06-01
卷号403期号:8页码:2173-2183
关键词Molecular imprinting Protein Antibody Recognition sites
通讯作者张丽华
产权排序1,1
英文摘要protein imprinting is a promising tool for generating artificial biomimetic receptors with antibody-like specific recognition sites. recently, protein-imprinted materials, as potential antibody substitutes, have attracted much attention in many fields, for example chemical sensors, chromatographic stationary phases, and artificial enzymes, owing to their long-term storage stability, potential re-usability, resistance to harsh environment, and low cost. in this critical review, we focus our discussion on the rational preparation of protein-imprinted materials in terms of choice of template, functional monomer, crosslinker, and polymerization format. in addition, several highlighted applications of protein-imprinted materials are emphasized, not only in well-known fields but also in some unique fields, for example proteomics and tissue engineering. finally, we propose challenges arising from the intrinsic properties of protein imprinting, for example obtaining the template, heterogeneous binding, and extrinsic competition, for example immobilized aptamers.
学科主题物理化学
WOS标题词science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]biochemical research methods ; chemistry, analytical
研究领域[WOS]biochemistry & molecular biology ; chemistry
关键词[WOS]unique electrophoresis technique ; minute structural differences ; artificial gel antibodies ; capillary-electrophoresis ; epitope approach ; liquid-chromatography ; universal method ; aqueous-media ; recognition ; polymers
收录类别SCI
语种英语
WOS记录号WOS:000305127200010
公开日期2013-10-11
内容类型期刊论文
源URL[http://159.226.238.44/handle/321008/118174]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,et al. Protein-imprinted materials: rational design, application and challenges[J]. analytical and bioanalytical chemistry,2012,403(8):2173-2183.
APA Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,&Zhang, Yukui.(2012).Protein-imprinted materials: rational design, application and challenges.analytical and bioanalytical chemistry,403(8),2173-2183.
MLA Yang, Kaiguang,et al."Protein-imprinted materials: rational design, application and challenges".analytical and bioanalytical chemistry 403.8(2012):2173-2183.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace