Protein-imprinted materials: rational design, application and challenges

	Protein-imprinted materials: rational design, application and challenges
	Yang, Kaiguang; Zhang, Lihua; Liang, Zhen; Zhang, Yukui
刊名	analytical and bioanalytical chemistry
	2012-06-01
卷号	403 期号:8 页码:2173-2183
关键词	Molecular imprinting Protein Antibody Recognition sites
通讯作者	张丽华
产权排序	1,1
英文摘要	protein imprinting is a promising tool for generating artificial biomimetic receptors with antibody-like specific recognition sites. recently, protein-imprinted materials, as potential antibody substitutes, have attracted much attention in many fields, for example chemical sensors, chromatographic stationary phases, and artificial enzymes, owing to their long-term storage stability, potential re-usability, resistance to harsh environment, and low cost. in this critical review, we focus our discussion on the rational preparation of protein-imprinted materials in terms of choice of template, functional monomer, crosslinker, and polymerization format. in addition, several highlighted applications of protein-imprinted materials are emphasized, not only in well-known fields but also in some unique fields, for example proteomics and tissue engineering. finally, we propose challenges arising from the intrinsic properties of protein imprinting, for example obtaining the template, heterogeneous binding, and extrinsic competition, for example immobilized aptamers.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	unique electrophoresis technique ; minute structural differences ; artificial gel antibodies ; capillary-electrophoresis ; epitope approach ; liquid-chromatography ; universal method ; aqueous-media ; recognition ; polymers
收录类别	SCI
语种	英语
WOS记录号	WOS:000305127200010
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/118174]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,et al. Protein-imprinted materials: rational design, application and challenges[J]. analytical and bioanalytical chemistry,2012,403(8):2173-2183.
APA	Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,&Zhang, Yukui.(2012).Protein-imprinted materials: rational design, application and challenges.analytical and bioanalytical chemistry,403(8),2173-2183.
MLA	Yang, Kaiguang,et al."Protein-imprinted materials: rational design, application and challenges".analytical and bioanalytical chemistry 403.8(2012):2173-2183.