Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer

doi:10.1016/j.colsurfb.2020.110837

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer
	Xing, Y ; Jiang, ZQ ; Akakuru, OU ; He, Y ; Li, AG ; Li, J ; Wu, AG
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2020
卷号	189 页码:-
关键词	METAL-ORGANIC FRAMEWORKS ONE-POT SYNTHESIS ZIF-90 MEMBRANE FAVORABLE BIOCOMPATIBILITY DRUG-RESISTANCE DELIVERY NANOPARTICLES SELECTIVITY DOXORUBICIN ATP
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2020.110837
文献子类	期刊论文
英文摘要	Epithelial ovarian cancer is still the leading cause of death in gynecology due to its resistance to platinum-based first-line chemotherapeutic drugs. The utilization of mitochondria-targeted drugs has become an important direction in anti-tumor drug research and development. In this work, cisplatin (DDP)-loaded ZIF-90 with mitochondrial-targeting was synthesized at room temperature with a high drug loading (11.7 %, calculated based on Pt content). The ZIF-90@DDP showed high cellular uptake and less toxicity in both non- and DDP-resistant ovarian cancer cells with effective pH- and ATP-responsive drug release. Both mitochondria-targeting and responsive drug release could increase the drug concentration in mitochondria of drug-resistant cancer cells to reverse such resistance. Conclusively, the mitochondria-targeting ZIF-90@DDP with high drug loading could trigger responsive drug release in mitochondria of epithelial ovarian cancer cells, inhibit DPP-resistant epithelial ovarian cancer cells, and reverse drug resistance.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33012]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Ningbo First Hosp, Dept Gynecol, Ningbo 315010, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Cixi Inst Biomed, Ningbo 315201, Peoples R China
推荐引用方式 GB/T 7714	Xing, Y,Jiang, ZQ,Akakuru, OU,et al. Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,189:-.
APA	Xing, Y.,Jiang, ZQ.,Akakuru, OU.,He, Y.,Li, AG.,...&Wu, AG.(2020).Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer.COLLOIDS AND SURFACES B-BIOINTERFACES,189,-.
MLA	Xing, Y,et al."Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer".COLLOIDS AND SURFACES B-BIOINTERFACES 189(2020):-.