Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation

doi:10.1021/acsabm.9b00960

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation
	Ren, Yue 4; Wang, Zi-Yang 4; Wei, Xin 4; Xu, Lu 2; Gul, Rizwan M.3; Huang, Shi-Shu 1; Xu, Jia-Zhuang 4; Li, Zhong-Ming 4
刊名	ACS Applied Bio Materials
	2020
卷号	3 期号:1 页码:547-553
关键词	Ultrahigh molecular weight polyethylenes Aliphatic compounds Arthroplasty Atoms Bearings (machine parts) Diffusion in liquids Free radical reactions Free radicals Joint prostheses Lipids Molecular weight Oxidative stress Oxygen Thermooxidation Wear resistance Accelerated aging Lipid peroxidation Oxidation mechanisms Oxidation products Oxidative degradation squalene Thermo oxidative aging Total joint replacement
ISSN号	2576-6422
DOI	10.1021/acsabm.9b00960
文献子类	期刊论文
英文摘要	Oxidative degradation of ultrahigh molecular weight polyethylene (UHMWPE) bearings is one of the main factors that deteriorates their mechanical properties and abrasive wear resistance, which further results in the failure of total joint replacements. Absorption and diffusion of synovial fluids have been considered as causes of the oxidation of UHMWPE bearings. However, the role of synovial fluids in oxidation of UHMWPE remains elusive. In this work, we aimed to reveal the oxidation mechanism of UHMWPE joints with respect to squalene (a representative component of the synovial fluid). The UHMWPE doped in squalene showed slight oxidation, while severe oxidation was observed when squalene doped UHMWPE was exposed to oxygen atmosphere. Squalene manifested lipid peroxidation with notable oxidation products and oxygen-derived free radicals during thermo-oxidative aging. Lipid peroxidation was deduced to follow two routes including autoxidation and thermal oxidation. The aggressive free radicals of squalene abstracted hydrogen atoms from the UHMWPE chains, initiating the oxidation of UHMWPE artificial joints. These findings not only provide evidence for comprehending the process of squalene-induced UHMWPE oxidation but also are instructive to develop highly oxidative-resistant UHMWPE. Copyright © 2019 American Chemical Society.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32943]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu; 610041, China 2.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai; 201899, China; 3.Department of Mechanical Engineering, University of Engineering and Technology, Peshawar; 25120, Pakistan; 4.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu; 610065, China;
推荐引用方式 GB/T 7714	Ren, Yue,Wang, Zi-Yang,Wei, Xin,et al. Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation[J]. ACS Applied Bio Materials,2020,3(1):547-553.
APA	Ren, Yue.,Wang, Zi-Yang.,Wei, Xin.,Xu, Lu.,Gul, Rizwan M..,...&Li, Zhong-Ming.(2020).Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation.ACS Applied Bio Materials,3(1),547-553.
MLA	Ren, Yue,et al."Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation".ACS Applied Bio Materials 3.1(2020):547-553.