Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body

doi:10.1111/cpr.12760

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body
	Li, HY ; Yin, YJ ; Yang, CQ ; Chen, M ; Wang, F ; Ma, C ; Li, H ; Kong, Y ; Ji, F ; Hu, J
刊名	CELL PROLIFERATION
	2020
卷号	53 期号:2 页码:-
关键词	CHANNELS FENESTRAE PROTEIN TRACER BRAIN FLOW
ISSN号	0960-7722
DOI	10.1111/cpr.12760
文献子类	期刊论文
英文摘要	Fluid in interstitial spaces accounts for similar to 20% of an adult body weight and flows diffusively for a short range. Does it circulate around the body like vascular circulations? This bold conjecture has been debated for decades. As a conventional physiological concept, interstitial space is a micron-sized space between cells and vasculature. Fluid in interstitial spaces is thought to be entrapped within interstitial matrix. However, our serial data have further defined a second space in interstitium that is a nanosized interfacial transport zone on a solid surface. Within this fine space, fluid along a solid fibre can be transported under a driving power and identically, interstitial fluid transport can be visualized by tracking the oriented fibres. Since 2006, our data from volunteers and cadavers have revealed a long-distance extravascular pathway for interstitial fluid flow, comprising at least four types of anatomic distributions. The framework of each extravascular pathway contains the longitudinally assembled and oriented fibres, working as a fibrorail for fluid flow. Interestingly, our data showed that the movement of fluid in a fibrous pathway is in response to a dynamic driving source and named as dynamotaxis. By analysis of previous studies and our experimental results, a hypothesis of interstitial fluid circulatory system is proposed.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32693]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China 2.Natl Ctr Gerontol, Beijing Hosp, Beijing, Peoples R China 3.Tsinghua Univ, Dept Engn Mech, Beijing, Peoples R China 4.Chinese Acad Med Sci, Inst Basic Med Sci, Neurosci Ctr, Dept Human Anat Histol & Embryol, Beijing, Peoples R China 5.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China 7.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Li, HY,Yin, YJ,Yang, CQ,et al. Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body[J]. CELL PROLIFERATION,2020,53(2):-.
APA	Li, HY.,Yin, YJ.,Yang, CQ.,Chen, M.,Wang, F.,...&Hu, J.(2020).Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body.CELL PROLIFERATION,53(2),-.
MLA	Li, HY,et al."Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body".CELL PROLIFERATION 53.2(2020):-.