Disrupted intrinsic functional brain topology in patients with major depressive disorder

doi:10.1038/s41380-021-01247-2

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	Disrupted intrinsic functional brain topology in patients with major depressive disorder
	Yang, Hong 41; Chen, Xiao 42,43,44; Chen, Zuo-Bing 45; Li, Le 1; Li, Xue-Ying 2,3,42; Castellanos, Francisco Xavier 4,5; Bai, Tong-Jian 6; Bo, Qi-Jing 7; Cao, Jun 8; Chang, Zhi-Kai 42,43
刊名	MOLECULAR PSYCHIATRY
	2021-08-12
页码	9
ISSN号	1359-4184
DOI	10.1038/s41380-021-01247-2
通讯作者	Yan, Chao-Gan(ycg.yan@gmail.com)
英文摘要	Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
收录类别	SCI
资助项目	National Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81820108018] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; China Postdoctoral Science Foundation[2019M660847] ; China National Postdoctoral Program for Innovative Talents[BX20200360] ; Key Project of Science and Technology Research Plan[2020-3-016] ; Key research and development program, Ministry of Science and Technology of People's Republic of China[2019YFC0121003] ; Basic Public Welfare Research Program of Zhejiang Province[LGF20H090013] ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain[NBSDC-DB-15]
WOS关键词	DEFAULT-MODE NETWORK ; CONNECTIVITY ; METAANALYSIS ; ABNORMALITIES ; INFORMATION ; REGIONS ; MATTER ; NAIVE
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:000684516400005
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Key Project of Science and Technology Research Plan ; Key research and development program, Ministry of Science and Technology of People's Republic of China ; Basic Public Welfare Research Program of Zhejiang Province ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/39988]
专题	心理研究所_中国科学院行为科学重点实验室
通讯作者	Yan, Chao-Gan
作者单位	1.Beijing Language & Culture Univ, Ctr Cognit Sci Language, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 3.Sinodanish Ctr Educ & Res, Beijing, Peoples R China 4.NYU, Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10003 USA 5.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA 6.Anhui Med Univ, Hefei, Anhui, Peoples R China 7.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 8.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China 9.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China 10.Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Yang, Hong,Chen, Xiao,Chen, Zuo-Bing,et al. Disrupted intrinsic functional brain topology in patients with major depressive disorder[J]. MOLECULAR PSYCHIATRY,2021:9.
APA	Yang, Hong.,Chen, Xiao.,Chen, Zuo-Bing.,Li, Le.,Li, Xue-Ying.,...&Yan, Chao-Gan.(2021).Disrupted intrinsic functional brain topology in patients with major depressive disorder.MOLECULAR PSYCHIATRY,9.
MLA	Yang, Hong,et al."Disrupted intrinsic functional brain topology in patients with major depressive disorder".MOLECULAR PSYCHIATRY (2021):9.