Deficit syndrome in Chinese patients with first-episode drug naive schizophrenia: Prevalence, demographic and clinical characteristics | |
Liu, Junyao1,2; Wang, Dongmei1,2; Zhou, Huixia1,2; Zhao, Ning Olivia3; Wu, Hanjing Emily3; Zhang, Xiangyang1,2 | |
刊名 | ASIAN JOURNAL OF PSYCHIATRY |
2021-11-01 | |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
卷号 | 65页码:5 |
关键词 | Schizophrenia Deficit syndrome Prevalence First-episode drug naive Risk factor |
ISSN号 | 1876-2018 |
DOI | 10.1016/j.ajp.2021.102861 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | Background: Deficit syndrome (DS) is a common subgroup of schizophrenia. However, few studies have examined the prevalence and risk factors for DS in Chinese Han patients with schizophrenia. The aim of this study was to assess prevalence, demographic and clinical characteristics of DS in Chinese Han patients with first-episode drug naive (FEDN) schizophrenia. Methods: In total, 235 patients with schizophrenia were recruited, and clinical and demographic data were collected. The Positive and Negative Syndrome Scale (PANSS) was utilized for the psychopathological symptoms, and the 17-item Hamilton Depression Rating Scale (HDRS-17) for depressive symptoms. The Proxy for the Deficit Syndrome (PDS) was adopted to identify DS. Results: The prevalence of DS in the cohort of first-episode schizophrenia patients was 23.0%. Compared to those patients without DS, patients with DS had younger age, lower education level, and were more likely to be single. Further, DS patients had significantly lower scores of positive symptoms, general psychopathology, and depression than non-DS patients. Patients with DS had fewer suicide attempts, but they had more severe negative symptoms and cognitive impairment (all p < 0.05). Multiple regression showed that poor cognitive functioning, lower levels of depression and younger age at onset were predictors of DS. Conclusions: Chinese Han patients with FEDN schizophrenia have high prevalence of DS. Some demographic and clinical parameters may be associated with DS. |
收录类别 | SCI |
资助项目 | CAS International Coopera-tion Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
WOS关键词 | PERSISTENT NEGATIVE SYMPTOMS ; SYNDROME SCALE ; 1ST EPISODE ; INSIGHT ; ASSOCIATION ; IMPAIRMENTS ; PREDICTORS ; PSYCHOSIS ; IMPACT ; TRIAL |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000701766200039 |
资助机构 | CAS International Coopera-tion Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40328] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Liu, Junyao,Wang, Dongmei,Zhou, Huixia,et al. Deficit syndrome in Chinese patients with first-episode drug naive schizophrenia: Prevalence, demographic and clinical characteristics[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,65:5. |
APA | Liu, Junyao,Wang, Dongmei,Zhou, Huixia,Zhao, Ning Olivia,Wu, Hanjing Emily,&Zhang, Xiangyang.(2021).Deficit syndrome in Chinese patients with first-episode drug naive schizophrenia: Prevalence, demographic and clinical characteristics.ASIAN JOURNAL OF PSYCHIATRY,65,5. |
MLA | Liu, Junyao,et al."Deficit syndrome in Chinese patients with first-episode drug naive schizophrenia: Prevalence, demographic and clinical characteristics".ASIAN JOURNAL OF PSYCHIATRY 65(2021):5. |
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