Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia

doi:10.1038/s41598-021-99510-7

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	Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
	Su, Xiuru 1; Qiao, Limin 3; Liu, Qing 2; Shang, Yujie 1; Guan, Xiaoni 5; Xiu, Meihong 5; Zhang, Xiangyang 4
刊名	SCIENTIFIC REPORTS
	2021-10-08
卷号	11 期号:1 页码:7
ISSN号	2045-2322
DOI	10.1038/s41598-021-99510-7
通讯作者	Xiu, Meihong(xiumeihong9797@gmail.com) ; Zhang, Xiangyang(zhangxy9@gmail.com)
英文摘要	Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naive first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients.
收录类别	SCI
资助项目	CAS Pioneer Hundred Talents Program
WOS关键词	NEUROTROPHIC FACTOR ; NEUROCOGNITIVE DEFICITS ; MAJOR DEPRESSION ; HUMAN-MEMORY ; ASSOCIATION ; VOLUME ; EXPRESSION ; HYPOTHESIS ; CLOZAPINE ; VARIANTS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000705243600077
资助机构	CAS Pioneer Hundred Talents Program
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40677]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Xiu, Meihong; Zhang, Xiangyang
作者单位	1.Hebei Prov Vet Hosp, Dept Psychiat, Baoding, Peoples R China 2.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 3.Lian Yang Community Hlth Serv Ctr, Shanghai, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 5.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China
推荐引用方式 GB/T 7714	Su, Xiuru,Qiao, Limin,Liu, Qing,et al. Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia[J]. SCIENTIFIC REPORTS,2021,11(1):7.
APA	Su, Xiuru.,Qiao, Limin.,Liu, Qing.,Shang, Yujie.,Guan, Xiaoni.,...&Zhang, Xiangyang.(2021).Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.SCIENTIFIC REPORTS,11(1),7.
MLA	Su, Xiuru,et al."Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia".SCIENTIFIC REPORTS 11.1(2021):7.