Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia | |
Zhou, Huixia3,4; Wang, Dongmei3,4; Wang, Jiesi3,4; Xu, Hang3,4; Cao, Bo1,2; Zhang, Xiangyang3,4 | |
刊名 | ASIAN JOURNAL OF PSYCHIATRY |
2021-10-01 | |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
卷号 | 64页码:6 |
关键词 | Cortical gyrification First-episode drug-naive schizophrenia Clinical symptoms Positive and negative syndrome scale |
ISSN号 | 1876-2018 |
DOI | 10.1016/j.ajp.2021.102749 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | Altered brain gyrification in diverse cortical regions has been reported in patients with schizophrenia, which possibly reflects deviations in early neurodevelopment. The main purpose of this study was to examine the relationship between clinical symptoms and abnormal cortical gyrification in drug-naive patients with schizophrenia in a Chinese Han population. We calculated the whole-brain cortical gyrification of 41 patients with first-episode drug-naive schizophrenia and 30 age- and sex-matched healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the psychopathology of patients with schizophrenia. Our results showed that compared to healthy controls, patients had higher cortical gyrification in the left lateral occipital cortex, but lower cortical gyrification in the left transverse temporal cortex. Moreover, the cortical gyrification in the left entorhinal cortex and left fusiform were both positively correlated with the general psychopathology of PANSS. Our findings indicate that abnormal cortical gyrification has occurred in the early stage of schizophrenia, suggesting that abnormal cortical gyrification may play an important role in the pathogenesis and symptomatology of schizophrenia. |
收录类别 | SCI |
资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; National Natural Sciences Foundation of China[31900777] |
WOS关键词 | PREFRONTAL GYRIFICATION ; CORTEX ; DISORDER ; COMPLEXITY ; RISK ; ABNORMALITIES ; CONNECTIVITY ; THICKNESS ; COGNITION ; UPDATE |
WOS研究方向 | Psychiatry |
出版者 | ELSEVIER |
WOS记录号 | WOS:000697027100017 |
资助机构 | CAS International Cooperation Research Program ; National Natural Sciences Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40310] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 2.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Huixia,Wang, Dongmei,Wang, Jiesi,et al. Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,64:6. |
APA | Zhou, Huixia,Wang, Dongmei,Wang, Jiesi,Xu, Hang,Cao, Bo,&Zhang, Xiangyang.(2021).Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,64,6. |
MLA | Zhou, Huixia,et al."Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 64(2021):6. |
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