Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia

doi:10.1097/FBP.0000000000000651

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia
	Guneri, Sinem 1,2,4; Scheel-Kruger, Jorgen 2,3; Luo, Fei 1,2,4
刊名	BEHAVIOURAL PHARMACOLOGY
	2021-10-01
卷号	32 期号:7 页码:571-580
关键词	acute pain complete Freund's adjuvant chronic pain formalin MK-801 rodent model schizophrenia spontaneous pain
ISSN号	0955-8810
DOI	10.1097/FBP.0000000000000651
通讯作者	Luo, Fei(luof@psych.ac.cn)
英文摘要	Patients diagnosed with schizophrenia have been reported to exhibit atypically low pain sensitivity and to vary in their experience of chronic pain. To the best of our knowledge, there has yet to be an animal study that provides information concerning the relationship between models of schizophrenia and pain. In the present study, we investigated several distinct nociceptive behaviors in a translational rat model of schizophrenia (0. 5 mg/kg MK-801, twice a day for 7 days followed by a 7-day washout period). The presence of the expected cognitive deficit was confirmed with novel object recognition (NOR) paradigm prior to nociception testing. MK-801-treated rats with lack of novelty interest in NOR testing showed: hyposensitivity to thermal and mechanical stimuli; short-term hypoalgesia followed by augmented hyperalgesia in response to formalin-induced spontaneous nociception and increased thermal and mechanical hyperalgesia in the complete Freund's adjuvant (CFA) induced chronic pain model. In conclusion, MK-801 induced antinociception effects for thermal stimuli in rats that were consistent with the decreased pain sensitivity observed in schizophrenia patients. Additionally, the amplified biphasic response exhibited by the MK-801 group in the formalin-induced spontaneous nociception test affirms the suitability of the test as a model of acute to delayed pain transition.
收录类别	SCI
资助项目	NNSF[31970926]
WOS关键词	NMDA-RECEPTOR ANTAGONIST ; FORMALIN TEST ; OBJECT RECOGNITION ; ANIMAL-MODEL ; SOCIAL-ISOLATION ; PAIN PERCEPTION ; MK-801 ; PHENCYCLIDINE ; KETAMINE ; HYPERALGESIA
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000695678500004
资助机构	NNSF
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40272]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Luo, Fei
作者单位	1.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 2.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 3.Aarhus Univ, Ctr Funct Integrat Neurosci, Dept Clin Med, Aarhus, Denmark 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Guneri, Sinem,Scheel-Kruger, Jorgen,Luo, Fei. Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia[J]. BEHAVIOURAL PHARMACOLOGY,2021,32(7):571-580.
APA	Guneri, Sinem,Scheel-Kruger, Jorgen,&Luo, Fei.(2021).Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia.BEHAVIOURAL PHARMACOLOGY,32(7),571-580.
MLA	Guneri, Sinem,et al."Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia".BEHAVIOURAL PHARMACOLOGY 32.7(2021):571-580.