Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor

doi:10.1155/2021/6686965

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor
	Bian, Li-hua 2; Yao, Zi-wei 2; Zhao, Cheng-bowen 2; Li, Qiu-yu 2; Shi, Jin-li 2; Guo, Jian-you 1
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2021-08-14
卷号	2021 页码:14
ISSN号	1741-427X
DOI	10.1155/2021/6686965
通讯作者	Shi, Jin-li(shijl@vip.sina.com) ; Guo, Jian-you(bioyou@126.com)
英文摘要	Nardostachyos Radix et Rhizoma (nardostachys) is the root and rhizome of Nardostachys jatamansi DC. Recent studies have shown that nardostachys may exert an anti-PD effect. In this study, the UHPLC-LTQ-Orbitrap-MS method was used to analyze the brain components of nardostachys in rats. Based on the results of UHPLC-LTQ-Orbitrap-MS analysis, nardosinone was identified to be the most effective anti-PD compound in nardostachys. To further verify this inference, a mouse PD model was established and the effect of nardosinone on PD mice was determined using classic behavioral tests. The results showed that nardosinone was indeed effective for relieving PD symptoms in mice. Moreover, network pharmacology analysis was used to elucidate the mechanism underlying the anti-PD effect of nardosinone. Dopamine receptor D2 (DRD2) was identified as the key target of nardosinone-PD interaction network, which was further verified by molecular docking and Western blotting. The results demonstrated that nardosinone and DRD2 could interact with each other. Furthermore, the expression level of DRD2 was decreased in the brain tissue of PD mice, and nardosinone could restore its expression to a certain extent. In conclusion, our findings suggest that nardosinone may reduce the motor and cognitive symptoms in the animal PD model by regulating DRD2 expression.
收录类别	SCI
资助项目	National Natural Science Foundation of China[81673560]
WOS关键词	NARDOSTACHYS-JATAMANSI ; NETWORK PHARMACOLOGY ; POLYMORPHISMS ; EXPOSURE ; DRD2 ; ASSOCIATION
WOS研究方向	Integrative & Complementary Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000687476200001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40112]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Shi, Jin-li; Guo, Jian-you
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China 2.Beijing Univ Chinese Med, Sch Chinese Mat Med, 11A North Third Ring East Rd, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Bian, Li-hua,Yao, Zi-wei,Zhao, Cheng-bowen,et al. Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,2021:14.
APA	Bian, Li-hua,Yao, Zi-wei,Zhao, Cheng-bowen,Li, Qiu-yu,Shi, Jin-li,&Guo, Jian-you.(2021).Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,14.
MLA	Bian, Li-hua,et al."Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021):14.