Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis

doi:10.3389/fnagi.2021.649874

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis
	Ren, Fuxin 2,3; Ma, Wen 4; Zong, Wei 2,3; Li, Ning 2,3; Li, Xiao 2,3; Li, Fuyan 2,3; Wu, Lili 5; Li, Honghao 1; Li, Muwei 6; Gao, Fei 2,3
刊名	FRONTIERS IN AGING NEUROSCIENCE
	2021-07-14
卷号	13 页码:14
关键词	presbycusis cognitive impairment low-frequency fluctuation frequency band functional connectivity
ISSN号	1663-4365
DOI	10.3389/fnagi.2021.649874
通讯作者	Gao, Fei(feigao6262@163.com)
英文摘要	Presbycusis (PC) is characterized by preferential hearing loss at high frequencies and difficulty in speech recognition in noisy environments. Previous studies have linked PC to cognitive impairment, accelerated cognitive decline and incident Alzheimer's disease. However, the neural mechanisms of cognitive impairment in patients with PC remain unclear. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored low-frequency oscillation (LFO) connectivity or amplitude of PC-related neural activity, it remains unclear whether the abnormalities occur within all frequency bands or within specific frequency bands. Fifty-one PC patients and fifty-one well-matched normal hearing controls participated in this study. The LFO amplitudes were investigated using the amplitude of low-frequency fluctuation (ALFF) at different frequency bands (slow-4 and slow-5). PC patients showed abnormal LFO amplitudes in the Heschl's gyrus, dorsolateral prefrontal cortex (dlPFC), frontal eye field and key nodes of the speech network exclusively in slow-4, which suggested that abnormal spontaneous neural activity in PC was frequency dependent. Our findings also revealed that stronger functional connectivity between the dlPFC and the posterodorsal stream of auditory processing, as well as lower functional coupling between the PCC and key nodes of the DMN, which were associated with cognitive impairments in PC patients. Our study might underlie the cross-modal plasticity and higher-order cognitive participation of the auditory cortex after partial hearing deprivation. Our findings indicate that frequency-specific analysis of ALFF could provide valuable insights into functional alterations in the auditory cortex and non-auditory regions involved in cognitive impairment associated with PC.
收录类别	SCI
资助项目	National Natural Science Foundation of China for Young Scholars[81601479] ; Taishan Scholars Project[tsqn201812147] ; China Postdoctoral Science Foundation[2017M621089] ; Jinan Science and Technology Development Program of China[201907097] ; Jinan Science and Technology Development Program of China[202019098] ; Shandong Provincial Medical and Healthy Technology Development Program of China[202009010449] ; Academic Promotion Programme of Shandong First Medical University[2019QL023]
WOS关键词	HEARING-LOSS ; OLDER-ADULTS ; FUNCTIONAL CONNECTIVITY ; WORKING-MEMORY ; MOTOR CORTEX ; PREVALENCE ; NETWORKS ; DEMENTIA ; GYRUS ; ADHD
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000678328100001
资助机构	National Natural Science Foundation of China for Young Scholars ; Taishan Scholars Project ; China Postdoctoral Science Foundation ; Jinan Science and Technology Development Program of China ; Shandong Provincial Medical and Healthy Technology Development Program of China ; Academic Promotion Programme of Shandong First Medical University
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40076]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Gao, Fei
作者单位	1.Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China 2.Shandong Univ, Cheeloo Coll Med, Shandong Prov Hosp, Dept Radiol, Jinan, Peoples R China 3.Shandong First Med Univ, Shandong Prov Hosp, Dept Radiol, Jinan, Peoples R China 4.Shandong Univ, Cheeloo Coll Med, Cent Hosp Jinan City, Dept Otolaryngol, Jinan, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Vanderbilt Univ Inst Imaging Sci, Nashville, TN USA
推荐引用方式 GB/T 7714	Ren, Fuxin,Ma, Wen,Zong, Wei,et al. Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis[J]. FRONTIERS IN AGING NEUROSCIENCE,2021,13:14.
APA	Ren, Fuxin.,Ma, Wen.,Zong, Wei.,Li, Ning.,Li, Xiao.,...&Gao, Fei.(2021).Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis.FRONTIERS IN AGING NEUROSCIENCE,13,14.
MLA	Ren, Fuxin,et al."Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis".FRONTIERS IN AGING NEUROSCIENCE 13(2021):14.