Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome | |
Tian, Hong5; Zhang, Bo1,2,3; Yu, Yanbing5; Zhen, Xueke5; Zhang, Li5; Yuan, Yue5; Wang, Liang4,6 | |
刊名 | BRAIN STIMULATION |
2021-05-01 | |
通讯作者邮箱 | yyb5185@126.com (y. yu) ; lwang@psych.ac.cn (l. wang) |
卷号 | 14期号:3页码:685-692 |
关键词 | Meige syndrome Deep brain stimulation Globus pallidus internus Neuronal activity Contact locations |
ISSN号 | 1935-861X |
DOI | 10.1016/j.brs.2021.04.005 |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been shown to be a safe and effective alternative therapy for ameliorating medically refractory primary Meige syndrome. However, the associations between DBS target position and surrounding electrophysiological properties as well as patients & rsquo; clinical outcomes remains largely unknown. In a large number of patients, we investigated electrophysiological features around stimulation targets and explored their roles in predicting clinical outcomes following bilateral GPi-DBS. Methods: The locations of DBS active contacts along the long axis of the GPi in a standard space were calculated and compared among three groups with different clinical outcomes. The firing rates of individual neurons within the GPi were calculated for each patient and compared across the three groups. Results: Compared with the bad group (poor clinical outcome), active contacts in the good group (good clinical outcome) and the best group (best clinical outcome) were located in the more posterior GPi. The average firing rates in the good and best groups were significantly higher than in the bad group, and this difference was pronounced within the ventral GPi. For the bad group, the average firing rates were significantly lower in the ventral than in the dorsal GPi. Conclusions: This study suggests that DBS of the posterior GPi may produce better clinical outcomes during primary Meige syndrome treatment and that higher GPi neuronal activity, particularly within the ventral part, can be used as a biomarker to guide DBS electrode implantation during surgery. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31771255] ; National Natural Science Foundation of China[32020103009] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD2018-07] ; Capital's Funds for Health Improvement and Research[2020-2-4061] ; Guizhou Science and Technology Plan Project (Qian Kehe platform talents)[[2017]5733-082] ; Guizhou Science and Technology Plan Project (Qian Kehe Basic)[ZK[2021] General 422] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515010785] |
WOS关键词 | SUBTHALAMIC NUCLEUS ; PARKINSONS-DISEASE ; NEURONAL-ACTIVITY ; DYSTONIA ; BLEPHAROSPASM ; DIAGNOSIS |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000654712000030 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/39664] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Yu, Yanbing; Wang, Liang |
作者单位 | 1.Zunyi Med Univ, Key Lab Brain Sci, Zunyi, Guizhou, Peoples R China 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen, Peoples R China 3.Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi, Guizhou, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.China Japan Friendship Hosp, Dept Neurosurg, Beijing, Peoples R China 6.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Tian, Hong,Zhang, Bo,Yu, Yanbing,et al. Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome[J]. BRAIN STIMULATION,2021,14(3):685-692. |
APA | Tian, Hong.,Zhang, Bo.,Yu, Yanbing.,Zhen, Xueke.,Zhang, Li.,...&Wang, Liang.(2021).Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome.BRAIN STIMULATION,14(3),685-692. |
MLA | Tian, Hong,et al."Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome".BRAIN STIMULATION 14.3(2021):685-692. |
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