A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf | |
Laura, Gertrude Foudjo Melacheu4; Njoya, Emmanuel Mfotie2,3; Jouda, Jean-Bosco4; Kweka, Brussine Nadege Wakeu4; Mbazoa, Celine Djama4; Wang, Fei3; Seguin, Elisabeth1; Wandji, Jean4 | |
刊名 | NATURAL PRODUCT RESEARCH |
2019 | |
页码 | 1628749 |
关键词 | Tabernaemontana inconspicua indole alkaloids cytotoxic activity |
ISSN号 | 1478-6419 |
DOI | 10.1080/14786419.2019.1628749 |
产权排序 | 2 |
文献子类 | Article; Early Access |
英文摘要 | One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 mu M and 2.19 mu M after 24 and 48 hours, respectively. [GRAPHICS] . |
学科主题 | Chemistry & Analysis |
URL标识 | 查看原文 |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | TAYLOR & FRANCIS LTD |
WOS记录号 | WOS:000478314300001 |
内容类型 | 期刊论文 |
源URL | [http://210.75.237.14/handle/351003/31064] |
专题 | 国家天然药物工程技术研究中心_天然产物研究 |
通讯作者 | Mbazoa, Celine Djama |
作者单位 | 1.Univ Rouen, Fac Med & Pharm, Lab Pharmacogniosie, Rouen 1, France 2.Univ Yaounde I, Fac Sci, Dept Biochem, Yaounde, Cameroon; 3.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China; 4.Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon; |
推荐引用方式 GB/T 7714 | Laura, Gertrude Foudjo Melacheu,Njoya, Emmanuel Mfotie,Jouda, Jean-Bosco,et al. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf[J]. NATURAL PRODUCT RESEARCH,2019:1628749. |
APA | Laura, Gertrude Foudjo Melacheu.,Njoya, Emmanuel Mfotie.,Jouda, Jean-Bosco.,Kweka, Brussine Nadege Wakeu.,Mbazoa, Celine Djama.,...&Wandji, Jean.(2019).A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf.NATURAL PRODUCT RESEARCH,1628749. |
MLA | Laura, Gertrude Foudjo Melacheu,et al."A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf".NATURAL PRODUCT RESEARCH (2019):1628749. |
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