Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

	Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry
	Qiao Xiao-Qiang 1,2,3; Wang Rui 1,2; Zhang Li-Hua 3; Yang Geng-Liang 1,2; Zhang Yu-Kui 3
刊名	chinese journal of analytical chemistry
	2012-07-01
卷号	40 期号:7 页码:1123-1129
关键词	Chemical derivatization High sensitive detection Mass spectrometry Peptide Review
通讯作者	乔晓强
产权排序	2,1
英文摘要	shotgun based strategy is a widely used method in proteome research. however, due to the high complexity and wide dynamic range, the detection sensitivity of peptides, especially for those with low abundance and low ionization efficiency, still can hardly meet the requirements. chemical derivatization has been proved to be one of the most promising methods. herein, the recent progress in the development of derivatization reagents targeting for the peptides as well as those with post-translational modifications, and its applications in high sensitive analysis in mass spectrometry are reviewed. furthermore, the future research directions and the potential application in proteome research are discussed.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, analytical
研究领域[WOS]	chemistry
关键词[WOS]	assisted-laser-desorption/ionization ; maldi-qit-tofmsn ; electrospray-ionization ; structural determination ; signal enhancement ; tryptic peptides ; ms/ms analysis ; amino-groups ; matrix ; oligosaccharides
收录类别	SCI
语种	英语
WOS记录号	WOS:000308253300005
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117804]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China 2.Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Qiao Xiao-Qiang,Wang Rui,Zhang Li-Hua,et al. Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry[J]. chinese journal of analytical chemistry,2012,40(7):1123-1129.
APA	Qiao Xiao-Qiang,Wang Rui,Zhang Li-Hua,Yang Geng-Liang,&Zhang Yu-Kui.(2012).Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry.chinese journal of analytical chemistry,40(7),1123-1129.
MLA	Qiao Xiao-Qiang,et al."Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry".chinese journal of analytical chemistry 40.7(2012):1123-1129.