Enantioselective Copper-Catalyzed Methylboration of Alkenes

doi:10.1021/acs.orglett.7b03860

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	Enantioselective Copper-Catalyzed Methylboration of Alkenes
	Chen, Bin 1,2,3; Cao, Peng 1; Liao, Yang 3; Wang, Min 3; Liao, Jian 2,3
刊名	ORGANIC LETTERS
	2018
卷号	20 期号:5 页码:1346-1349
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b03860
产权排序	1
文献子类	Article
英文摘要	An enantioselective Cu-catalyzed borylative cross coupling reaction of alkenes, bis(pinacolato)diboron (B-2(pin)(2)), and methyl iodide is reported. Alkenes including styrenes, beta-substituted styrenes, and challenging aliphatic olefins were smoothly transferred to the desired methylboration products with excellent diastereoselectivities (dr up to >99:1) and enantioselectivities (er up to 99:1). The utility of this process was demonstrated by the synthesis of naproxen and formal synthesis of two natural products.
学科主题	Organic Chemistry ; Polymer Science
URL标识	查看原文
WOS关键词	STEREOSELECTIVE-SYNTHESIS ; COPPER(I)-CATALYZED REACTION ; CARBOBORATION ; ARYLBORATION ; ALKYNES ; ALKYLBORATION ; LIGAND ; CYCLIZATION ; EFFICIENT ; IMINES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000426804200021
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30850]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Sichuan, Peoples R China 2.Sichuan Univ, Coll Chem Engn, Chengdu 610065, Sichuan, Peoples R China; 3.Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China and University of Chinese Academy of Sciences, Beijing 10049, People’s Republic of China;
推荐引用方式 GB/T 7714	Chen, Bin,Cao, Peng,Liao, Yang,et al. Enantioselective Copper-Catalyzed Methylboration of Alkenes[J]. ORGANIC LETTERS,2018,20(5):1346-1349.
APA	Chen, Bin,Cao, Peng,Liao, Yang,Wang, Min,&Liao, Jian.(2018).Enantioselective Copper-Catalyzed Methylboration of Alkenes.ORGANIC LETTERS,20(5),1346-1349.
MLA	Chen, Bin,et al."Enantioselective Copper-Catalyzed Methylboration of Alkenes".ORGANIC LETTERS 20.5(2018):1346-1349.