Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology

doi:10.1016/j.aca.2019.02.046

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	Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology
	Fu, Xian 1,2; Xia, Bing 2; Ji, Baocheng 1,2; Lei, Shan 1,2; Zhou, Yan 2
刊名	ANALYTICA CHIMICA ACTA
	2019
卷号	1065 页码:64-70
关键词	Paper-based microfluidic analytical devices 3D printing Electric field Airflow Flow controllability
ISSN号	0003-2670
DOI	10.1016/j.aca.2019.02.046
产权排序	1
文献子类	Article
英文摘要	In most cases, three-dimensional paper-based microfluidic analytical devices (3D-mu PADs) were fabricated manually by stacking or folding methods. For the first time, digital light processing stereolithography (DLP-SLA) 3D printing technology was adopted to automatically make 3D-mu PADs. In the fabrication process, a printing pause was set between two layers to allow paper to be placed in the resin tank. The resin on the fresh paper spontaneously bonded to the former cured paper layer during curing, thus realizing the automatic bonding and alignment between different layers of paper and avoiding the human participation and errors as in stacking and folding methods. There was a gap between two vertical aligned flow paths, therefore the liquid did not flow spontaneously from the upper layer to the lower layer. Most of the fluid flow in 3D-mu PADs was spontaneous or manually activated, which was not conducive to complex assays that require different regents to be delivered sequentially. Herein, we used an electric field or airflow to trigger the fluid flow and demonstrated the flow controllability by a proof-of-concept colorimetric assay. The limits of detection of glucose and albumin were 0.8 mM and 3.5 mu M, respectively, which were sufficient for clinical requirements. Given the characteristic of flow controllability, we believe that the proposed 3D-mu PADs have great potential to make paper-based complex assays automated and programmable. (C) 2019 Elsevier B.V. All rights reserved.
学科主题	Chemistry & Analysis
URL标识	查看原文
WOS关键词	PATTERNED PAPER ; URIC-ACID ; LOW-COST ; GLUCOSE ; PERFORMANCE ; PROTEIN ; ASSAYS ; TIME
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000464926000008
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30524]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, 93 South Keyuan Rd, Chengdu 610041, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Fu, Xian,Xia, Bing,Ji, Baocheng,et al. Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology[J]. ANALYTICA CHIMICA ACTA,2019,1065:64-70.
APA	Fu, Xian,Xia, Bing,Ji, Baocheng,Lei, Shan,&Zhou, Yan.(2019).Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology.ANALYTICA CHIMICA ACTA,1065,64-70.
MLA	Fu, Xian,et al."Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology".ANALYTICA CHIMICA ACTA 1065(2019):64-70.