Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway

doi:10.1016/j.cbpc.2019.02.004

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院环境与应用微生物重点实验室

	Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway
	Ding, Li 1; Li, Weihao 1; Li, Na 1; Liang, Lingyue 1; Zhang, Xinying 1; Jin, Huilin 1; Shi, Haitao 1,3; Storey, Kenneth B.2; Hong, Meiling 1
刊名	COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
	2019
卷号	219 页码:59-67
关键词	Invasive species Salinity adaptation Antioxidative enzymes Nrf2-Keapl TOR-S6K1 MDA
ISSN号	1532-0456
DOI	10.1016/j.cbpc.2019.02.004
产权排序	2
文献子类	Article
英文摘要	The red-eared slider (Trachemys scripta elegans), a freshwater turtle, is an invasive species in many parts of the world where it survives in both freshwater and coastal saline habitats. High salinity can induce reactive oxygen species (ROS) production and lead to oxidative damage. In this study, we investigate the antioxidant defense mechanisms of T. s. elegans in response to salinity stress. The results showed that the mRNA expression levels of superoxide dismutase (SODs), catalase (CAT) and glutathione peroxidase (GSH-PXs) were significantly increased in both 5 psu and 15 psu groups at the early stages of salinity exposure (generally 6-48 h), but typically returned to control levels after the longest 30 d exposure. In addition, hepatic and cardiac mRNA levels of the NF-E2-related factor 2 (Nrf2), showed a similar upregulation as an early response to stress, but decreased at 30 d in the 5 psu and 15 psu groups. The mRNA levels of the negative regulator of Nrf2, kelch-like ECH associating protein 1 (Keap1), exhibited the opposite pattern. Moreover, mRNA expression levels of target of rapamycin (TOR) and ribosomal protein S6 kinase 1 (S6K1) in liver and heart showed roughly similar patterns to those for Nrf2. Furthermore, the content of malondialdehyde (MDA) was significantly increased in liver, especially in the 15 psu group by similar to 2.5-fold. Taken together, these results indicate that T. s. elegans may activate the TOR-Nrf2 pathway to modulate antioxidant genes transcription in order to promote enhanced antioxidant defense in response to salinity stress.
学科主题	Pharmacology & Toxicology
URL标识	查看原文
WOS关键词	ENZYME-ACTIVITIES ; GLUTATHIONE-PEROXIDASE ; MOLECULAR-MECHANISMS ; NRF2-KEAP1 PATHWAY ; KEAP1-NRF2 PATHWAY ; OXIDATIVE STRESS ; TURTLE ; ACTIVATION ; EXPRESSION ; ANOXIA
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000462801500007
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30953]
专题	食品安全与环境治理领域_中国科学院环境与应用微生物重点实验室
通讯作者	Hong, Meiling
作者单位	1.Hainan Normal Univ, Coll Life Sci, Key Lab Ecol Trop Isl, Minist Educ, Haikou, Hainan, Peoples R China; 2.Carleton Univ, Dept Biol, Ottawa, ON K1S 5B6, Canada 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Ding, Li,Li, Weihao,Li, Na,et al. Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2019,219:59-67.
APA	Ding, Li.,Li, Weihao.,Li, Na.,Liang, Lingyue.,Zhang, Xinying.,...&Hong, Meiling.(2019).Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,219,59-67.
MLA	Ding, Li,et al."Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 219(2019):59-67.