Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411

doi:10.1021/acs.jafc.8b05628

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 食品安全与环境治理领域 > 应用与环境微生物研究

	Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411
	Tang, Jia-Lin 1,2; Zhou, Zong-Yuan 1,2; Yang, Tao 2; Yao, Can 2; Wu, Lin-Wei 2; Li, Guo-You 2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2019
卷号	67 期号:8 页码:2175-2182
关键词	Penicillium sclerotiorum azaphilones anti-inflammatory activity cytotoxicity
ISSN号	0021-8561
DOI	10.1021/acs.jafc.8b05628
产权排序	1
文献子类	Article
英文摘要	Nine new azaphilone alkaloids, penazaphilones A-I (1-9), were isolated from the solid fermented rice culture of Penicillium sclerotiorum cib-411. The structures of compounds 1-9 were elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures of 5 and 8 were confirmed by X-ray crystallographic analyses. Biological evaluation showed that compounds 1, 5, 6, and 8 inhibited the production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide with IC50 values of 15.29, 9.34, 9.50, and 7.05 mu M, respectively. Meanwhile, they did not exhibit obvious cytotoxicity at a concentration of 50.0 mu M.
学科主题	Agricultural Chemistry
URL标识	查看原文
WOS关键词	ORANGE PIGMENTS ; DERIVATIVES ; METABOLITES ; YELLOW ; STRAIN
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000460200000008
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30500]
专题	环境治理与食品安全领域_应用与环境微生物研究
通讯作者	Li, Guo-You
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Tang, Jia-Lin,Zhou, Zong-Yuan,Yang, Tao,et al. Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(8):2175-2182.
APA	Tang, Jia-Lin,Zhou, Zong-Yuan,Yang, Tao,Yao, Can,Wu, Lin-Wei,&Li, Guo-You.(2019).Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(8),2175-2182.
MLA	Tang, Jia-Lin,et al."Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.8(2019):2175-2182.