The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures

doi:10.1016/j.saa.2021.120172

	The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures
	Lin, Dongyue 1,2,3; He, Yao 1; Dong, Ronglu 1,2; Li, Wei 1; Meng, Fanli 4; Zhang, Yunfeng 5; Yang, Liangbao 1,3
刊名	SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
	2021-12-15
卷号	263
关键词	Surface enhanced Raman scattering High affinity Succinylcholine chloride Gold nanorods Human plasma
ISSN号	1386-1425
DOI	10.1016/j.saa.2021.120172
通讯作者	Zhang, Yunfeng(17020395@qq.com) ; Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要	Succinylcholine chloride (SCC) is a common poison that threatens human life. At present, there is a lack of research on its on-site rapid detection methods. In this work, the use of gold nanorods as an enhanced substrate based on the high affinity between the quaternary ammonium salt structure can achieve rapid SERS detection of SCC in plasma. The long alkane chain structure of cetyltrimethylammonium bromide (CTAB) and the quaternary ammonium salt structure of SCC have a high molecular affinity, so that the target molecule can show a strong and obvious characteristic signal of SERS. Combined with a simple pretreatment method, acetonitrile is used as a protein precipitation agent to effectively remove matrix interference. The constructed SERS substrate can achieve the sensitive detection of 2 x 10(-8) M level of SCC in plasma samples and has high detection reproducibility. The entire pre-processing and testing process can be completed within 7 min, which can be used as an important technical basis for the preliminary identification of on-site SCC-related drug cases. The research results provide an effective solution for the establishment of SCC analysis strategies in complex matrices, and can provide new ideas for solving the problems of difficult identification of common poisons in the field and the lack of rapid detection methods on site. (C) 2021 Elsevier B.V. All rights reserved.
资助项目	National Science Foundation of China[61605221] ; National Science Foundation of China[21974142] ; National Science Foundation of China[62033002] ; Open project of Beijing Engineering Technology Research Center for On-site Evidence Inspection[2020CSEEKFKT07]
WOS关键词	ENHANCED RAMAN-SPECTROSCOPY ; REFLECTANCE INFRARED MICROSPECTROSCOPY ; SENSITIVE DETECTION ; SCATTERING ; CHOLINE ; NANOPARTICLES ; MOLECULES ; PROTEIN ; METAL
WOS研究方向	Spectroscopy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000691514800023
资助机构	National Science Foundation of China ; Open project of Beijing Engineering Technology Research Center for On-site Evidence Inspection
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125183]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Yunfeng; Yang, Liangbao
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Peoples R China 4.Northeastern Univ, Shenyang 110819, Peoples R China 5.Inst Forens Sci, Minist Publ Secur, Beijing 100038, Peoples R China
推荐引用方式 GB/T 7714	Lin, Dongyue,He, Yao,Dong, Ronglu,et al. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2021,263.
APA	Lin, Dongyue.,He, Yao.,Dong, Ronglu.,Li, Wei.,Meng, Fanli.,...&Yang, Liangbao.(2021).The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,263.
MLA	Lin, Dongyue,et al."The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 263(2021).