Natural orifice specimen extraction surgery versus conventional laparoscopic-assisted resection for colorectal cancer in elderly patients: a propensity-score matching study

doi:10.1007/s13304-021-01143-y

	Natural orifice specimen extraction surgery versus conventional laparoscopic-assisted resection for colorectal cancer in elderly patients: a propensity-score matching study
	Zhang, Hao 1; Hu, Hanqing 1; Huang, Rui 1; Guan, Zilong 1; Zheng, Mingyu 1; Xu, Chao 1; Li, Zhengliang 1; Wang, Yuliuming 1; Zhang, Weiyuan 1; Yu, Lei 1
刊名	UPDATES IN SURGERY
	2021-08-09
关键词	Natural orifice specimen extraction surgery Colorectal cancer Elderly patients Survival
ISSN号	2038-131X
DOI	10.1007/s13304-021-01143-y
通讯作者	Wang, Guiyu(guiywang@163.com) ; Wang, Xishan(wxshan_1208@126.com)
英文摘要	Whether natural orifice specimen extraction surgery (NOSES) could provide beneficial effects in treating elderly patients is still under debate. The aim of the study was to compare the clinical outcomes of transanal NOSES with conventional laparoscopic-assisted resection (LA) in elderly colorectal cancer (CRC) patients. A retrospective analysis from the Second Affiliated Hospital of Harbin Medical University between 2013 and 2017 was performed. Outcomes related to surgery, body image, quality of life, anal function and long-term survival were compared between the two groups with the propensity-score matching (PSM) method. After PSM, 78 patients were successfully compared. Patients with NOSES had faster gastrointestinal function recovery (P = 0.028), less postoperative complications (P = 0.025), lower pain scores on days 1, 3 and 5 after surgery (P < 0.001). The body image score (P < 0.001) and cosmetic score (P < 0.001) were significantly higher in the NOSES group than the LA group at 1 month after surgery. Patients with NOSES posed better global health status (P < 0.001), role function (P = 0.009), emotional function (P = 0.011) and social function (P = 0.011) at 3 months after surgery. Moreover, NOSES showed non inferiority in anal function 6 months after surgery. No significant difference could be found regarding to overall survival (OS), disease-free survival (DFS), local recurrence (LR) and distant metastasis (DM). In elderly CRC patients, NOSES harbored favorable postoperative outcomes, excellent cosmetic properties and better quality of life. Besides, anal function and long-term outcomes of NOSES can be sure for elderly patients.
资助项目	National Provincial Natural Fund[H2017016] ; National Natural Science Foundation of China[81872034] ; Wu Jieping Medical Foundation[320.6750.19092-41]
WOS关键词	SURVIVAL OUTCOMES ; COLECTOMY ; TRIAL
WOS研究方向	Surgery
语种	英语
出版者	SPRINGER-VERLAG ITALIA SRL
WOS记录号	WOS:000683254500001
资助机构	National Provincial Natural Fund ; National Natural Science Foundation of China ; Wu Jieping Medical Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123087]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Guiyu; Wang, Xishan
作者单位	1.Harbin Med Univ, Dept Colorectal Surg, Affiliated Hosp 2, Harbin, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Colorectal Surg, Canc Hosp, Hangzhou, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Colorectal Surg, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hao,Hu, Hanqing,Huang, Rui,et al. Natural orifice specimen extraction surgery versus conventional laparoscopic-assisted resection for colorectal cancer in elderly patients: a propensity-score matching study[J]. UPDATES IN SURGERY,2021.
APA	Zhang, Hao.,Hu, Hanqing.,Huang, Rui.,Guan, Zilong.,Zheng, Mingyu.,...&Wang, Xishan.(2021).Natural orifice specimen extraction surgery versus conventional laparoscopic-assisted resection for colorectal cancer in elderly patients: a propensity-score matching study.UPDATES IN SURGERY.
MLA	Zhang, Hao,et al."Natural orifice specimen extraction surgery versus conventional laparoscopic-assisted resection for colorectal cancer in elderly patients: a propensity-score matching study".UPDATES IN SURGERY (2021).