Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B

doi:10.6023/cjoc1108081

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 资源化学研究室

	Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B
	Zhao Jiangyu ; Aisa Haji Akber
刊名	CHINESE JOURNAL OF ORGANIC CHEMISTRY
	2012
卷号	32 期号:2 页码:333-337
关键词	Rupestonic Acid Isoxazole Derivative Influenza Virus Inhibitory Activity
ISSN号	0253-2786
DOI	10.6023/cjoc1108081
英文摘要	To improve biological activity of rupestonic acid, six rupestonic acid amide derivatives containing isoxazole were synthesized in the presence of DCC, HOBt/DMAP using the rupestonic acid and 3-aryl-5-isoxazole-methylamine as the starting materials. The synthesized compounds 3a similar to 3f were confirmed by the methods of H-1 NMR, C-13 NMR, IR, ESI-MS techniques and preliminarily assayed in vitro against influenza viruses A and B. The results showed that compound 3c showed better activity against both influenza viruses A (H3N2) and B, and compounds 3c and 3e had the higher inhibition against influenza B virus than the parent compound 1.
学科主题	Chemistry
WOS记录号	WOS:000301616200011
公开日期	2012-11-29
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/1641]
专题	新疆理化技术研究所_资源化学研究室
通讯作者	Zhao Jiangyu
作者单位	1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Zhao Jiangyu,Aisa Haji Akber. Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):333-337.
APA	Zhao Jiangyu,&Aisa Haji Akber.(2012).Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(2),333-337.
MLA	Zhao Jiangyu,et al."Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.2(2012):333-337.