Separation and scavenging superoxide radical activity of chitooligomers with degree of polymerization 6-16

	Separation and scavenging superoxide radical activity of chitooligomers with degree of polymerization 6-16
	Li, Kecheng 1,2; Xing, Ronge1 ; Liu, Song 1; Qin, Yukun 1,2; Li, Bing 1,2; Wang, Xueqin 1,2; Li, Pengcheng1
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2012-12-01
卷号	51 期号:5 页码:826-830
关键词	Fully deacetylated chitooligomers Degree of polymerization 6-16 Separation Scavenging superoxide radical activity
ISSN号	0141-8130
通讯作者	Liu, S (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
英文摘要	The separation of chitooligomers (COS) with well-defined degree of polymerization (DP) is of interest to further study their bioactivity. However, there has been no report on separation of chitooligomers with DP>6 and the activity of these oligomers is unknown. This paper focuses on separating COS with DP > 6 and five fractions were separated from the prepared fully deacetylated chitooligomers mixture by CM Sepharose Fast Flow column and analyzed by HPLC, which mainly contained glucosamine oligomers with DP6-7 (41.31%, 50.22%), DP7-8 (22.47%, 70.13%), DP9-10 (53.06%, 27.99%), DP10-12 (18.45%, 49.36%, 22.31%), and DP>12, respectively. The superoxide radical scavenging activity of each fraction was investigated. The oligomers with DP ranging from 10 to 12 exhibited higher scavenging activity than other fractions and in combination with the DP distribution of fractions, it was further concluded that the chitooligomers with DP11 was likely to be optimal for scavenging superoxide radical activity. (C) 2012 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology
收录类别	SCI
原文出处	10.1016/j.ijbiomac.2012.07.031
语种	英语
WOS记录号	WOS:000311196100021
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12243]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Kecheng,Xing, Ronge,Liu, Song,et al. Separation and scavenging superoxide radical activity of chitooligomers with degree of polymerization 6-16[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2012,51(5):826-830.
APA	Li, Kecheng.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Li, Bing.,...&Li, Pengcheng.(2012).Separation and scavenging superoxide radical activity of chitooligomers with degree of polymerization 6-16.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,51(5),826-830.
MLA	Li, Kecheng,et al."Separation and scavenging superoxide radical activity of chitooligomers with degree of polymerization 6-16".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 51.5(2012):826-830.