Flounder (Paralichthys olivaceus) FoxD1 and its regulation on the expression of myogenic regulatory factor, MyoD

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	Flounder (Paralichthys olivaceus) FoxD1 and its regulation on the expression of myogenic regulatory factor, MyoD
	Zhang, Yuqing 1,2; Tan, Xungang1 ; Sun, Wei 1,2; Zhang, Pei-Jun 1
刊名	BIOLOGIA
	2012-10-01
卷号	67 期号:5 页码:992-1000
关键词	flounder FoxD1 protein over-expression muscle development
ISSN号	0006-3088
通讯作者	Tan, XG (reprint author), Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
英文摘要	It has been reported that FoxD1 plays important roles in formation of several different tissues, such as retina and kidney in vertebrates. The function of FoxD1 in muscle development is, however, unclear although it is expressed in muscle cells in zebrafish. Muscles are the major tissue in fish, which serves as a rich protein source in our diet. To further understand the function of FoxD1 in fish muscle development, here we isolated and characterized the FoxD1 gene from flounder (Paralichthys olivaceus), a valuable sea food and an important fish species in aquaculture in Asia. We analyzed its expression pattern and function in regulating myogenic regulatory factor, MyoD, one of the earliest marker of myogenic commitment. In situ hybridization revealed that FoxD1 was expressed in the tailbud, adaxial cells, posterior intestine, forebrain, midbrain and half of the retina in flounder embryos. Functional studies demonstrated that when flounder FoxD1 was over-expressed in zebrafish by microinjection, MyoD expression was decreased, suggesting that FoxD1 may be involved in myogenesis by regulating the expression of MyoD.
学科主题	Biology
收录类别	SCI
原文出处	10.2478/s11756-012-0096-8
语种	英语
WOS记录号	WOS:000307767300022
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12330]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yuqing,Tan, Xungang,Sun, Wei,et al. Flounder (Paralichthys olivaceus) FoxD1 and its regulation on the expression of myogenic regulatory factor, MyoD[J]. BIOLOGIA,2012,67(5):992-1000.
APA	Zhang, Yuqing,Tan, Xungang,Sun, Wei,&Zhang, Pei-Jun.(2012).Flounder (Paralichthys olivaceus) FoxD1 and its regulation on the expression of myogenic regulatory factor, MyoD.BIOLOGIA,67(5),992-1000.
MLA	Zhang, Yuqing,et al."Flounder (Paralichthys olivaceus) FoxD1 and its regulation on the expression of myogenic regulatory factor, MyoD".BIOLOGIA 67.5(2012):992-1000.