A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma
	Wang, Cuicui 1,2; Liu, Ming 1; Cheng, Linyou 1,2; Wei, Jianteng 1,2; Wu, Ning 1,2; Zheng, Lanhong 1; Lin, Xiukun 1,3
刊名	EXPERIMENTAL BIOLOGY AND MEDICINE
	2012-04-01
卷号	237 期号:4 页码:442-450
关键词	Meretrix meretrix Linnaeus antitumor polypeptide non-small-cell lung carcinoma G(2)/M phase arrest apoptosis
ISSN号	1535-3702
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
英文摘要	A novel polypeptide (Mere15) was purified from Meretrix meretrix Linnaeus by ammonium sulfate fractionation, ion exchange, gel filtration and reversed phase chromatography. Mere15 exhibited selective cytotoxicity to several human cancer cells. In vivo study showed that Mere15 significantly suppressed the growth of human lung adenocarcinoma A549 xenograft in nude mice. The mechanism was associated with a G(2)/M phase arrest followed by apoptosis, including membrane blebbing, loss of mitochondrial membrane potential, externalization of phosphatidylserine, chromosome condensation and DNA fragmentation. Western blot analysis showed that the intrinsic pathway was involved in Mere15-induced apoptosis. These results suggest that Mere15 may have therapeutic potential for the treatment of non-small-cell lung carcinoma.
学科主题	Medicine, Research & Experimental
收录类别	SCI
原文出处	10.1258/ebm.2012.011337
语种	英语
WOS记录号	WOS:000304515100013
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12265]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Wang, Cuicui,Liu, Ming,Cheng, Linyou,et al. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(4):442-450.
APA	Wang, Cuicui.,Liu, Ming.,Cheng, Linyou.,Wei, Jianteng.,Wu, Ning.,...&Lin, Xiukun.(2012).A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.EXPERIMENTAL BIOLOGY AND MEDICINE,237(4),442-450.
MLA	Wang, Cuicui,et al."A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma".EXPERIMENTAL BIOLOGY AND MEDICINE 237.4(2012):442-450.