Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides

doi:10.1039/d1ra01522b

	Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides
	Yuan, Jiaqi 1,2; Zhang, Xiaofei 1; Yang, Chunhao 1,2
刊名	RSC ADVANCES
	2021-04-23
卷号	11 期号:23 页码:13832-13838
DOI	10.1039/d1ra01522b
通讯作者	Zhang, Xiaofei(xiaofeizhang@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要	Herein, direct alkylation of the C-H bond at the alpha-position of furans catalyzed by palladium catalyst is reported. This protocol targets alpha-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.
资助项目	Science and Technology Commission of Shanghai Municipality[18431907100] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120185003] ; State Key Laboratory of Drug Research Program[SIMM1903ZZ-03]
WOS关键词	HYDROHETEROARYLATION ; HETEROARENES ; DISCOVERY ; SECONDARY ; PYRIDINE ; ALKENES ; DESIGN ; POTENT ; ACID
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000641127700016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296543]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Xiaofei; Yang, Chunhao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Jiaqi,Zhang, Xiaofei,Yang, Chunhao. Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides[J]. RSC ADVANCES,2021,11(23):13832-13838.
APA	Yuan, Jiaqi,Zhang, Xiaofei,&Yang, Chunhao.(2021).Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides.RSC ADVANCES,11(23),13832-13838.
MLA	Yuan, Jiaqi,et al."Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides".RSC ADVANCES 11.23(2021):13832-13838.